{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:52:31Z","timestamp":1793760751994,"version":"4.6.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["14\u2010126"],"award-info":[{"award-number":["14\u2010126"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["4072\u2010B28"],"award-info":[{"award-number":["4072\u2010B28"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Deproteinized bovine bone mineral (DBBM) is not resorbable. However, the behavior of DBBM under inflammatory conditions remains unclear. Aim of the study was\u00a0therefore to evaluate the resorption of DBBM under local inflammatory conditions in vivo using the calvarial osteolysis model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In thirty adult BALB\/c mice, DBBM was implanted into the space between the elevated soft tissue and the calvarial bone. Inflammation was induced either by lipopolysaccharides (LPS) injection or by polyethylene particles (Ceridust) mixed with DBBM. Three modalities were randomly applied (<jats:italic>n<\/jats:italic>\u00a0=\u00a010 each): (a) DBBM alone (control), (b) DBBM\u00a0+\u00a0LPS, and (c) DBBM\u00a0+\u00a0polyethylene particles (Ceridust). Mice were euthanized on day fourteen, and each calvarium was subjected to histological and \u00b5CT analysis. Primary outcome was the size distribution of the DBBM particles. Secondary outcome was the surface erosion of the calvarial bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histological and \u00b5CT analysis revealed that the size distribution and the volume of DBBM particles in the augmented site were similar between DBBM alone and the combinations with LPS or polyethylene particles. Moreover, histological evaluation showed no signs of erosions of DBBM particles under inflammatory conditions. \u00b5CT analysis and histology further revealed that LPS and the polyethylene particles, but not the DBBM alone, caused severe erosions of the calvarial bone as indicated by large voids representing the massive compensatory new immature woven bone formation on the endosteal surface.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Local calvarial bone but not the DBBM particles undergo severe resorption and subsequent new bone formation under inflammatory conditions in a mouse model.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13538","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T09:45:16Z","timestamp":1568713516000},"page":"10-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["DBBM shows no signs of resorption under inflammatory conditions. An experimental study in the mouse calvaria"],"prefix":"10.1111","volume":"31","author":[{"given":"Ulrike","family":"Kuchler","sequence":"first","affiliation":[{"name":"Department of Oral Surgery University Clinic of Dentistry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Mulinari","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Integrated Clinic Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d Ara\u00e7atuba Dental School Ara\u00e7atuba Brazil"},{"name":"Core Facility Hard Tissue and Biomaterial Research Karl Donath Laboratory University Clinic of Dentistry Medical University of Vienna Vienna Austria"},{"name":"Department of Oral Biology University Clinic of Dentistry Medical University of Vienna Vienna 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