{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:11:26Z","timestamp":1788207086076,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the biological and aesthetic outcome of connective tissue grafting around single\u2010tooth implant replacements in the anterior maxilla after five years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Nineteen patients (mean age: 22) received 33 implants in combination with bone grafts. After healing, 10 implant sites received facial connective tissue grafts harvested from the palate (test group). The remaining 23 implant sites without soft tissue grafts were used as a control group. The biological outcomes included survival rate, complications, marginal bone level, keratinized mucosa height and soft tissue level. The aesthetic outcomes included soft tissue thickness, spectrophotometric colour of mucosa, 3D facial dimensional changes and professional reported aesthetic outcomes. All data were recorded preoperatively and postoperatively after six months and one, three and five years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After five years, the survival and success rate of implants was 100% and 93.9% (one aesthetic and one biological complication). The soft tissue level changed significantly more towards the incisal direction in the test than in the control group from one to five years of observation (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.024). The facial dimension increased significantly more in the test group than in the control group (3\u00a0mm marginally: <jats:italic>p<\/jats:italic>\u00a0=\u00a0.010). The subjective evaluation of mucosa colour was significantly better in the test versus control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.035). Other biological and aesthetic parameters were not significantly different between the test and control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Augmentation using a connective tissue graft may result in better mucosal colour match and more facial dimensional gain compared to implant sites without soft tissue grafting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13540","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T09:43:45Z","timestamp":1568713425000},"page":"18-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Tissue changes at implant sites in the anterior maxilla with and without connective tissue grafting: A five\u2010year prospective study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8768-274X","authenticated-orcid":false,"given":"Mandana","family":"Hosseini","sequence":"first","affiliation":[{"name":"Section of Oral Rehabilitation Department of Odontology Faculty of Health Science University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Worsaae","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Gotfredsen","sequence":"additional","affiliation":[{"name":"Section of Oral Rehabilitation Department of Odontology Faculty of Health Science University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,27]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"11","article-title":"The long\u2010term efficacy of currently used dental implants: A review and proposed criteria of success","volume":"1","author":"Albrektsson T.","year":"1986","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"416","article-title":"Implant associated soft tissue defects in the anterior maxilla: A randomized control trial comparing subepithelial connective tissue graft and acellular dermal matrix allograft","volume":"23","author":"Anderson L. 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