{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:13:27Z","timestamp":1792325607468,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G091218N"],"award-info":[{"award-number":["G091218N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010648","name":"Universitaire Ziekenhuizen Leuven, KU Leuven","doi-asserted-by":"publisher","award":["C24\/17\/086"],"award-info":[{"award-number":["C24\/17\/086"]}],"id":[{"id":"10.13039\/501100010648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Examine the clinical and microbiological benefits of a dual\u2010strain <jats:italic>Lactobacillus reuteri<\/jats:italic> probiotic on the non\u2010surgical therapy of initial peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This randomized, double\u2010blind study targeted patients with initial peri\u2010implantitis, that is peri\u2010implantitis with a maximum mean probing pocket depth of 6\u00a0mm and maximum 3\u00a0mm bone loss compared with loading. A full\u2010mouth prophylaxis was performed and the peri\u2010implantitis sites were debrided. Subsequently, local application of the study drops was carried out at the peri\u2010implantitis sites and the study lozenges were handed out. The patients in the probiotic group received drops and lozenges containing <jats:italic>L.\u00a0reuteri<\/jats:italic> (ATCC PTA 5289 &amp; DSM 17938), those in the control group received placebo products. At the implant level the measurements of interest were bleeding, probing pocket depth and plaque. Full\u2010mouth bleeding and plaque scores were also recorded. Microbiological samples were taken from the tongue, saliva and subgingivally around the implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All clinical parameters were significantly decreased after 12 and 24\u00a0weeks. At the implant level the only statistically significant difference was a greater decrease in plaque levels in the probiotic versus the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002 at 24\u00a0weeks). At the full\u2010mouth level, the only intergroup difference was the greater decrease in full\u2010mouth bleeding on probing sites in the probiotic group compared with the control group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001 at 24\u00a0weeks). Concerning the microbiological outcomes, no significant differences could be found at any time point, neither intra\u2010 nor intergroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No adjunctive effects of the use of <jats:italic>L.\u00a0reuteri<\/jats:italic> probiotics in the treatment of peri\u2010implantitis were found.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13555","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T10:35:42Z","timestamp":1573295742000},"page":"84-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["The usage of a lactobacilli probiotic in the non\u2010surgical therapy of peri\u2010implantitis: A randomized pilot study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9662-8238","authenticated-orcid":false,"given":"Isabelle","family":"Laleman","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences KU Leuven &amp; Dentistry University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Pauwels","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences KU Leuven &amp; Dentistry University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Quirynen","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences KU Leuven &amp; Dentistry University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Teughels","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences KU Leuven &amp; Dentistry University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12155"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01291.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515608832"},{"issue":"6","key":"e_1_2_8_6_1","first-page":"775","article-title":"The effect of orally administered probiotic Lactobacillus reuteri\u2010containing tablets in peri\u2010implant mucositis: A double\u2010blind randomized controlled trial","volume":"50","author":"Flichy\u2010Fernandez A. 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