{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:57:26Z","timestamp":1769727446683,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002878","name":"Consejer\u00eda de Econom\u00eda, Innovaci\u00f3n, Ciencia y Empleo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CTS\u20101028"],"award-info":[{"award-number":["CTS\u20101028"]}],"id":[{"id":"10.13039\/501100002878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002878","name":"Consejer\u00eda de Econom\u00eda, Innovaci\u00f3n, Ciencia y Empleo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CTS\u2010138"],"award-info":[{"award-number":["CTS\u2010138"]}],"id":[{"id":"10.13039\/501100002878","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyze a modified biphasic phycogenic biomaterial in comparison with anorganic bovine bone in maxillary sinus floor elevation in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Eight male patients in need of bilateral two\u2010stage sinus floor elevation were consecutively recruited for this randomized split\u2010mouth study. A combination of autogenous cortical bone (ACB, 20%) and anorganic bovine bone (ABB, 80%) (ACB\u00a0+\u00a0ABB group) or ACB (20%) and modified biphasic phycogenic material (BP, 80%) (ACB\u00a0+\u00a0BP group) were randomly assigned to graft each sinus. Patients were followed up for 6\u00a0months post\u2010surgery when bone samples were collected for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Radiographically, bone height gain was statistically higher in the ACB\u00a0+\u00a0ABB versus the ACB\u00a0+\u00a0BP group. While the analysis of the biological compartments showed differences in non\u2010mineralized tissue (39.15\u00a0\u00b1\u00a020.97% vs. 65.87\u00a0\u00b1\u00a028.59%, ACB\u00a0+\u00a0ABB vs. ACB\u00a0+\u00a0BP respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.018) and remnant biomaterial particles (22.62\u00a0\u00b1\u00a017.01% vs. 7.96\u00a0\u00b1\u00a08.57%, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.028), the percentage of mineralized tissue (38.23\u00a0\u00b1\u00a017.55% vs. 24.14\u00a0\u00b1\u00a024.66%, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.398) showed no statistically significant difference. In contrast, ACB\u00a0+\u00a0ABB biopsies showed higher Musashi\u20101\u2010positive cells per mm<jats:sup>2<\/jats:sup> compared to ACB\u00a0+\u00a0BP biopsies (811.49\u00a0\u00b1\u00a0875.30 vs. 236.90\u00a0\u00b1\u00a0280.81; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.018), where the fusiform cells corresponded mainly with fibroblasts, as demonstrated by ultrastructural analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both combinations of materials exhibited bone formation after 6\u00a0months of healing in the maxillary sinus cavity. However, the combination with biphasic phycogenic biomaterial induced a higher radiographical vertical resorption and graft collapse in comparison with the combination with anorganic bovine bone, possibly due to a higher remodeling of the graft.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13590","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T08:01:40Z","timestamp":1582099300000},"page":"536-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Algae\u2010derived hydroxyapatite behavior as bone biomaterial in comparison with anorganic bovine bone: A split\u2010mouth clinical, radiological, and histologic randomized study in humans"],"prefix":"10.1111","volume":"31","author":[{"given":"Pablo","family":"Galindo\u2010Moreno","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry School of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-1341","authenticated-orcid":false,"given":"Miguel","family":"Padial\u2010Molina","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry School of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Lopez\u2010Chaichio","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry School of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Guti\u00e9rrez\u2010Garrido","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry School of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natividad","family":"Mart\u00edn\u2010Morales","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry School of Dentistry University of Granada Granada Spain"},{"name":"Department of Pathology and IBIMER School of Medicine University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"O'Valle","sequence":"additional","affiliation":[{"name":"Department of Pathology and IBIMER School of Medicine University of Granada Granada Spain"},{"name":"Instituto Biosanitario de Granada (ibs.GRANADA) University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090686"},{"key":"e_1_2_10_3_1","first-page":"1230","article-title":"Influence of lateral window dimensions on vital bone formation following maxillary sinus augmentation","volume":"27","author":"Avila\u2010Ortiz G.","year":"2012","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.10.037"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12380"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.08.020"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.00987.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12741"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01337.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13098"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01148.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12112"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2012.00445.x"},{"key":"e_1_2_10_14_1","first-page":"42","article-title":"Immunohistochemical osteopontin expression in bone xenograft in clinical series of maxillary sinus lift","volume":"1","author":"Galindo\u2010Moreno P.","year":"2015","journal-title":"Journal of Oral Science & Rehabilitation"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01814.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02073.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3182691959"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01827.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02308.x"},{"key":"e_1_2_10_20_1","first-page":"505","article-title":"Guest editorial: 1996 sinus consensus conference revisited in 2016","volume":"31","author":"Jensen O.","year":"2016","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01605.x"},{"key":"e_1_2_10_22_1","first-page":"930","article-title":"Three\u2010dimensional analysis of bone formation after maxillary sinus augmentation by means of microcomputed tomography: A pilot study","volume":"25","author":"K\u00fchl S.","year":"2010","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_10_23_1","first-page":"E537","article-title":"Sinus elevation by in situ utilization of bone scrapers: Technique and results","volume":"12","author":"Martos Diaz P.","year":"2007","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/sia.3337"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.4801"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13419"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29908-3"},{"key":"e_1_2_10_28_1","first-page":"681456","article-title":"Osteoarticular expression of Musashi\u20101 in an experimental model of arthritis","volume":"2015","author":"O'Valle F.","year":"2015","journal-title":"BioMed Research International"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092171"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/341327"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-011-0296-3"},{"key":"e_1_2_10_32_1","first-page":"336","article-title":"Bone regeneration with algae\u2010derived hydroxyapatite: A pilot histologic and histomorphometric study in rabbit tibia defects","volume":"27","author":"Scarano A.","year":"2012","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j..2003.00959.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01097.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000003636"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13144"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00621-5"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.02.015"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.01.006"},{"key":"e_1_2_10_40_1","first-page":"433","article-title":"Measurement of volume changes after sinus floor augmentation with a phycogenic hydroxyapatite","volume":"21","author":"Wanschitz F.","year":"2005","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01150.x"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.13590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.13590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/clr.13590","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.13590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T11:57:16Z","timestamp":1694001436000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.13590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/clr.13590"],"URL":"https:\/\/doi.org\/10.1111\/clr.13590","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,6]]},"assertion":[{"value":"2019-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}