{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:34:36Z","timestamp":1792679676598,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["YRG to Dr. Mario Romandini (project n. 15\u2010251)"],"award-info":[{"award-number":["YRG to Dr. Mario Romandini (project n. 15\u2010251)"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the prevalence of peri\u2010implant diseases and to identify risk\/protective indicators of peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Two hundred and forty randomly selected patients from a university clinic database were invited to participate. Those who accepted, once data from their medical and dental history were collected, were examined clinically and radiographically to assess the prevalence of peri\u2010implant health and diseases. Peri\u2010implantitis was defined as the presence of BoP\/SoP together with radiographic bone levels (BL) \u22672\u00a0mm. An intermediate peri\u2010implant health category between peri\u2010implant mucositis and peri\u2010implantitis was also identified, defined by the presence of BoP\/SoP together with 1\u00a0mm \u2266BL\u00a0&lt;\u00a02\u00a0mm. A multilevel multivariate logistic regression analysis was carried out to identify those factors associated either positively (risk) or negatively (protective) with peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety\u2010nine patients with a total of 458 dental implants were analyzed. The prevalences of pre\u2010periimplantitis and of peri\u2010implantitis were, respectively, 31.3% and 56.6% at patient\u2010level, while 31.7% and 27.9% at implant level. The following factors were identified as risk indicators for peri\u2010implantitis: smoking (OR\u00a0=\u00a03.59; 95% CI: 1.52\u20138.45), moderate\/severe periodontitis (OR\u00a0=\u00a02.77; 95% CI: 1.20\u20136.36), &lt;16 remaining teeth (OR\u00a0=\u00a02.23; 95% CI: 1.05\u20134.73), plaque (OR\u00a0=\u00a03.49; 95% CI: 1.13\u201310.75), implant malposition (too vestibular: OR\u00a0=\u00a02.85; 95% CI: 1.17\u20136.93), implant brand (Nobel vs. Straumann: OR\u00a0=\u00a04.41;95% CI: 1.76\u201311.09), restoration type (bridge vs. single crown: OR\u00a0=\u00a02.47; 95% CI: 1.19\u20135.12), and trauma as reason of tooth loss (vs. caries: OR\u00a0=\u00a06.51; 95% CI: 1.45\u201329.26). Conversely, the following factors were identified as protective indicators: interproximal flossing\/brushing (OR\u00a0=\u00a00.27; 95% CI: 0.11\u20130.68), proton pump inhibitors (OR\u00a0=\u00a00.08; 95% CI: 0.01\u20130.90), and anticoagulants (OR\u00a0=\u00a00.08; 95% CI: 0.01\u20130.56).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Peri\u2010implant diseases are highly prevalent among patients with dental implants in this university\u2010based population. Several factors were identified as risk\u2010 and protective\u2010 indicators of peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.13684","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T23:22:47Z","timestamp":1605828167000},"page":"112-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":235,"title":["Prevalence and risk\/protective indicators of peri\u2010implant diseases: A university\u2010representative cross\u2010sectional study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-083X","authenticated-orcid":false,"given":"Mario","family":"Romandini","sequence":"first","affiliation":[{"name":"Section of Graduate Periodontology Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Lima","sequence":"additional","affiliation":[{"name":"Section of Graduate Periodontology Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Pedrinaci","sequence":"additional","affiliation":[{"name":"Section of Graduate Periodontology Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Araoz","sequence":"additional","affiliation":[{"name":"Section of Graduate Periodontology Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Costanza","family":"Soldini","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universitat Internacional de Catalunya Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Section of Graduate Periodontology Faculty of Odontology University Complutense Madrid Spain"},{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010implant Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13204"},{"issue":"2","key":"e_1_2_9_3_1","first-page":"123","article-title":"Nonsurgical treatment for peri\u2010implant mucositis: A systematic review and meta\u2010analysis","volume":"13","author":"Barootchi S.","year":"2020","journal-title":"International Journal of Oral Implantology (New Malden, London, England)"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13138"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12738"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12813"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2012.01.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518818479"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13137"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01819.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12772"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13095"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515608832"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12535"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12334"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110664"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01001.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12049"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12832"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01375.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13585"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12953"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12910"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12369"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12829"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0951-9"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13416"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01872.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515622432"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0471"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170135"},{"issue":"3","key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1160\/TH14-11-0947","article-title":"Platelets, inflammation and anti\u2010inflammatory effects of antiplatelet drugs in ACS and CAD","volume":"114","author":"M\u00fcller K. A. L.","year":"2015","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-02943-8"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0599"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2276-y"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0124"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13250"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12956"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13628"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13287"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13017"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.7465"},{"key":"e_1_2_9_44_1","article-title":"Clinical signs, symptoms, perceptions and impact on quality of life of patients suffering from peri\u2010implant diseases: a university\u2010representative cross\u2010sectional study","author":"Romandini M.","year":"2020","journal-title":"Clinical Oral Implants Research"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00908.x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01837.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"crossref","DOI":"10.1002\/JPER.19-0490","article-title":"Factors associated with the presence of peri\u2010implant buccal soft tissue dehiscences: A case\u2010control study","author":"Sanz\u2010Mart\u00edn I.","year":"2020","journal-title":"Journal of Periodontology"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12954"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12954"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01831.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577511"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13111"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13397"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.13684","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/clr.13684","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.13684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T03:49:57Z","timestamp":1693712997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.13684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,29]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/clr.13684"],"URL":"https:\/\/doi.org\/10.1111\/clr.13684","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.06.04.20121970","asserted-by":"object"}]},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,29]]},"assertion":[{"value":"2020-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}