{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:51:22Z","timestamp":1787597482812,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare two ridge preservation techniques and spontaneous healing in terms of hard and soft tissue changes 2\u00a0months after tooth extraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The study was designed as a randomized controlled trial and included 75 patients. After single tooth extraction in the maxillary incisor\/premolar area, patients were randomly allocated to one of the following groups: (a) ridge preservation with a xenogeneic bone substitute covered with a collagen matrix (CM\u2010group), (b) ridge preservation with a xenogeneic bone substitute covered with a free palatal graft (PG\u2010group) or (c) spontaneous healing (control). Eight weeks after tooth extraction, implants were placed and clinical, profilometric and radiographic evaluations were performed. In addition, the need for further guided bone regeneration (GBR) at implant placement was assessed. The differences between the treatment groups were compared with the One\u2010way ANOVA or Kruskal\u2013Wallis test with the corresponding post hoc analysis. The proportions of the categorical parameters were compared with the Fisher\u00b4s exact test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010five patients underwent early implant placement 8\u00a0weeks after tooth extraction and were evaluated. CM\u2010group (\u22120.9\u00a0<jats:italic>SD<\/jats:italic> 0.6\u00a0mm) and PG\u2010group (\u22121.0\u00a0<jats:italic>SD<\/jats:italic> 0.8\u00a0mm) showed less horizontal bone resorption compared to the control group (\u22123.2\u00a0<jats:italic>SD<\/jats:italic> 2.1\u00a0mm) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Moreover, the necessity of GBR at implant placement was significantly less in CM\u2010group (32%) and PG\u2010group (24%) when compared to control group (72%) (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.001). Patients in CM\u2010group experienced less pain than PG\u2010group, one week after tooth extraction (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.042). No significant differences were found regarding graft evaluation, post\u2010operative complications, and soft tissue contour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ridge preservation using a xenogeneic bone substitute covered with a collagen matrix or a palatal graft, results in less bone resorption and fewer GBR procedures at early implant placement compared to spontaneous healing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13686","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T06:17:25Z","timestamp":1605939445000},"page":"123-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Soft tissue contour and radiographic evaluation of ridge preservation in early implant placement: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0100-3871","authenticated-orcid":false,"given":"Brend Pjotr","family":"Jonker","sequence":"first","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Special Dental Care and Orthodontics Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Gil","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry Center of Dental Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Naenni","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry Center of Dental Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-1320","authenticated-orcid":false,"given":"Ronald Ernst","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry Center of Dental Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eppo Bonne","family":"Wolvius","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Special Dental Care and Orthodontics Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Pijpe","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Special Dental Care and Orthodontics Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Department of Oral &amp; Maxillofacial Surgery Catharina Hospital Eindhoven Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12366"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13057"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12357"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080360"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12167"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513506713"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515592869"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01381.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050296"},{"key":"e_1_2_8_11_1","volume-title":"Cochrane handbook for systematic reviews of interventions version 6.1","author":"Higgings J. 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