{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:42:15Z","timestamp":1781260935014,"version":"3.54.1"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the histomorphometric outcomes obtained in randomized clinical trials (RCTs) with different biomaterials used for maxillary sinus augmentation (MSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A search of the existing medical literature until October 1, 2019, was performed. Inclusion criteria were (a) RCTs assessing a two\u2010stage MSA from the lateral approach using autologous bone or biomaterials for grafting and (b) reported histomorphometric outcomes based on crestal bone core biopsy samples. The Bayesian method was used to perform pairwise meta\u2010analyses and network meta\u2010analysis (NMA). The primary outcome, the new bone percentage (NB %), was calculated as mean differences with 95% credible intervals. The interventions were ranked by their posterior probability by calculating the surface under the cumulative ranking curve values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four RCTs (842 MSAs) were included in the analysis with a normal healing period (5\u20138\u00a0months). All comparisons were presented in a league table. On the basis of the ranking probability, the most effective bone grafting material for NB% was bovine xenograft\u00a0+\u00a0bone marrow concentrate (BMC) (81%), followed by bovine xenograft\u00a0+\u00a0platelet\u2010rich plasma (PRP) (77%), bioactive glass ceramic\u00a0+\u00a0autologous bone 1:1 (70%), nanocrystalline hydroxyapatite in silica gel (70%), and bioactive glass ceramic (70%). Autologous bone graft alone took the twelfth position with 57%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitations of the present NMA, the analysis did not confirm autologous bone alone as the gold standard for MSA and showed superiority of composite grafts such as bovine xenograft\u00a0+\u00a0BMC after 5\u20138\u00a0months of healing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13690","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T08:26:46Z","timestamp":1606206406000},"page":"135-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Relative performance of various biomaterials used for maxillary sinus augmentation: A Bayesian network meta\u2010analysis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2308-2312","authenticated-orcid":false,"given":"B\u00e1lint","family":"Trimmel","sequence":"first","affiliation":[{"name":"Department of Oral Diagnostics Faculty of Dentistry Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mi","family":"Gede","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine Medical School University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-7259","authenticated-orcid":false,"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine Medical School University of P\u00e9cs P\u00e9cs Hungary"},{"name":"Szent\u00e1gothai Research Centre University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7035-941X","authenticated-orcid":false,"given":"Zsolt","family":"Szak\u00e1cs","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine Medical School University of P\u00e9cs P\u00e9cs Hungary"},{"name":"Szent\u00e1gothai Research Centre University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6ngyi Anna","family":"Mezey","sequence":"additional","affiliation":[{"name":"Department of Public Health Faculty of Medicine University of Szeged Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Varga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical School University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0728-7027","authenticated-orcid":false,"given":"M\u00e1rton","family":"Kivovics","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry Faculty of Dentistry Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4830-5658","authenticated-orcid":false,"given":"Lilla","family":"Han\u00e1k","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine Medical School University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Rumbus","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine Medical School University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5828-6078","authenticated-orcid":false,"given":"Gy\u00f6rgy","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Oro\u2010Maxillofacial Surgery and Stomatology Faculty of Dentistry Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2019.05.004"},{"key":"e_1_2_9_3_1","first-page":"S219","article-title":"Augmentation procedures using bone substitute materials or autogenous bone \u2010 a systematic review and meta\u2010analysis","volume":"7","author":"Al\u2010Nawas B.","year":"2014","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.6417"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090686"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02270.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-019-0166-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02036.x"},{"key":"e_1_2_9_9_1","first-page":"613","article-title":"Grafting of the maxillary sinus floor with autogenous marrow and bone","volume":"38","author":"Boyne P. 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