{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:28:09Z","timestamp":1793140089434,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate the influence of real implant\u2010bed\u2010specific radiation doses on peri\u2010implant tissue health in head and neck cancer (HNC) patients after radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Specific radiation doses in the area of 81 implants, in 15 irradiated HNC patients, were analyzed by matching data from the radiotherapy planning system with those of three\u2010dimensional follow\u2010up scans after implantation. Peri\u2010implant bone resorption was measured radiographically after 1 and 3\u00a0years, and peri\u2010implant tissue health was evaluated clinically. Individual parameters, such as age, gender, and localization, regarding the implant\u2010specific radiation dose distribution were analyzed statistically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean implant\u2010bed\u2010specific radiation dose was high, with 45.95\u00a0Gy to the mandible and 29.02\u00a0Gy to the maxilla, but significantly lower than the mean total dose to the tumor bed. Peri\u2010implant bone resorption correlated with local inflammation and plaque. After 1\u00a0year, women temporarily showed significantly more bone loss than men and implant\u2010specific radiation dose had a significant impact on peri\u2010implant bone loss after 3\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presented method is a feasible option to define precise implant\u2010bed\u2010specific radiation doses for research or treatment planning purposes. Implant\u2010based dental restoration after radiotherapy is a relatively safe procedure, but a negative radiation dose\u2010dependent long\u2010term effect on peri\u2010implant bone resorption calls for interdisciplinary cooperation between surgeons and radio\u2010oncologists to define high\u2010risk areas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13696","type":"journal-article","created":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T00:26:25Z","timestamp":1607214385000},"page":"249-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Influence of implant\u2010specific radiation doses on peri\u2010implant hard and soft tissue: An observational pilot study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5477-623X","authenticated-orcid":false,"given":"Norbert","family":"Neckel","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Wagendorf","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sachse","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Stromberger","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Radiotherapy Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstin","family":"Vach","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry and Medical Statistics Faculty of Medicine and Medical Center University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Heiland","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Nahles","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","article-title":"Peri\u2010implantitis diagnosis and prognosis using biomarkers in peri\u2010Implant crevicular fluid: A narrative review","volume":"9","author":"Alassy H.","year":"2019","journal-title":"Diagnostics (Basel)"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(03)00124-8"},{"issue":"7","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1600-0501.2008.01534.x-i2","article-title":"Impact of local and systemic factors on the incidence of late oral implant loss","volume":"19","author":"Alsaadi G.","year":"2008","journal-title":"Clinical Oral Implants Research"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2001.27515"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2009.12.007"},{"key":"e_1_2_9_7_1","volume-title":"TNM classification of malignant tumours","author":"Brierley J. 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