{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:39:12Z","timestamp":1792035552723,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Previous studies have indicated that xerostomia is a critical factor affecting periodontitis; nonetheless, it is controversial whether xerostomia impairs peri\u2010implant tissue. The objective of this experimental study was to evaluate the effect of xerostomia on the peri\u2010implant hard and soft tissues in the rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Implants were placed in bilateral maxillae of male Wistar rats. The animals underwent submandibular and sublingual gland resection on both sides (DRY group) or sham operation (CTR group). Silk ligatures were placed around one side of abutments, which were randomly selected in each animal. The effects of xerostomia were assessed using micro\u2010CT, histological analysis, real\u2010time PCR, and 16S rRNA\u2010based metagenomic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ligation with silk thread caused bone resorption around implants. Although xerostomia itself did not induce bone resorption, it significantly enhanced silk ligature\u2010mediated bone resorption around implants. Histological analysis and real\u2010time PCR indicated that xerostomia induced inflammation and osteoclastogenesis around implants with silk ligatures. Furthermore, it altered the microbiota of the plaque on the silk thread around implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Xerostomia accelerates mucosal inflammation and osteoclastogenesis, which aggravates bone resorption around implants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13727","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T08:09:17Z","timestamp":1614240557000},"page":"581-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Xerostomia aggravates ligation\u2010induced peri\u2010implantitis: A preclinical in vivo study"],"prefix":"10.1111","volume":"32","author":[{"given":"Yusuke","family":"Hori","sequence":"first","affiliation":[{"name":"Division of Oral Reconstruction and Rehabilitation Kyushu Dental University Kitakyushu 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