{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:15:47Z","timestamp":1792275347318,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Compared to autografts, bone graft substitutes are slower to consolidate. If we understood why, this might open strategies to accelerate new bone formation and thus shorten the time to implant placement. In this study, we aimed at comparing autologous bone graft with a bovine bone graft substitute in a preclinical sinus lift model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The mouse posterior paranasal sinus served as a recipient site for grafting. Autograft from the oral cavity was compared against bone graft substitute using molecular, cellular, and histological analyses conducted on post\u2010grafting days (PSD) 0, 9, 18, and 120.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Either autografts or bone graft substitutes were positioned on the sinus floor and remained in situ throughout the study. At the time of grafting and until day 9, bone graft substitutes were devoid of cells and alkaline phosphatase (ALP) activity while autografts were comprised of viable cells and showed strong ALP (mineralization) activity. Consequently, new bone formed faster in autografts compared to bone graft substitutes (140.21\u00a0\u00b1\u00a041.21\u00a0\u00b5m vs. 41.70\u00a0\u00b1\u00a010.09\u00a0\u00b5m, respectively, PSD9,<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0143). By PSD18, osteogenesis was evident in autografted and xenografted sites. Osteoclasts identified by tartrate resistant acid phosphatase attached to, but did not resorb the bone graft substitute matrix. Autograft matrix, however, underwent extensive resorption. Transgenic mice revealed that Wnt\u2010responsive osteoprogenitor cells originated primarily from the internal periosteum of the maxillary bone, and not from the Schneiderian membrane.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Autografts produce new bone sooner, but bovine bone graft substitutes eventually consolidate and then resist resorption. Enhancing osteoprogenitor cell recruitment to a bone graft substitute constitutes a viable strategy for accelerating bone formation in a sinus lift procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13781","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T07:46:42Z","timestamp":1621928802000},"page":"916-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Biology of sinus floor augmentation with an autograft versus a bone graft substitute in a preclinical in vivo experimental model"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0105-6703","authenticated-orcid":false,"given":"Benjamin R.","family":"Coyac","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery School of Medicine Stanford University Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery School of Medicine Stanford University Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Bahat","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery School of Medicine Stanford University Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery School of Medicine Stanford University Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0463-396X","authenticated-orcid":false,"given":"Jill A.","family":"Helms","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery School of Medicine Stanford University Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"49","article-title":"Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement?","volume":"22","author":"Aghaloo T. L.","year":"2007","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34133"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00656.x"},{"issue":"7","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/j.1600-0501.2008.01539.x-i2","article-title":"Histomorphometric assessment of bone formation in sinus augmentation utilizing a combination of autogenous and hydroxyapatite\/biphasic tricalcium phosphate graft materials: At 6 and 9 months in humans","volume":"19","author":"Artzi Z.","year":"2008","journal-title":"Clinical Oral Implants Research"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00323-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1998.090301.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199810001-00006"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2013.08.022"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2020.06.003"},{"key":"e_1_2_10_12_1","first-page":"237","article-title":"Bone augmentation procedures in implant dentistry","volume":"24","author":"Chiapasco M.","year":"2009","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01077.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2012.00445.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.07.007"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01062.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160X-5-12"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/307168a0"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000202085.23454.2F"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140182"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12218"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2010.0035"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.113312"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12165"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12649"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511422718"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200407000-00029"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13052"},{"issue":"2","key":"e_1_2_10_30_1","first-page":"S203","article-title":"Autogenous bone harvesting and grafting in advanced jaw resorption: Morbidity, resorption and implant survival","volume":"7","author":"Nkenke E.","year":"2014","journal-title":"European Journal of Oral Implantology"},{"issue":"4","key":"e_1_2_10_31_1","first-page":"498","article-title":"Influence of particle size of autogenous bone grafts on the early stages of bone regeneration: A histologic and stereologic study in rabbit calvarium","volume":"17","author":"Pallesen L.","year":"2002","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v013a01"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0391398818771530"},{"issue":"3","key":"e_1_2_10_34_1","first-page":"205","article-title":"Three\u2010dimensional analysis of rodent paranasal sinus cavities from X\u2010ray computed tomography (CT) scans","volume":"73","author":"Phillips J. E.","year":"2009","journal-title":"Canadian Journal of Veterinary Research"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012003279.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0304-7"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2015.12.003"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-017-0084-4"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.03.009"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-008-9202-x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01835.x"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2970"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(22)02107-3"},{"issue":"3","key":"e_1_2_10_44_1","first-page":"321","article-title":"In vitro osteoclast resorption of bone substitute biomaterials used for implant site augmentation: A pilot study","volume":"17","author":"Taylor J. C.","year":"2002","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060308"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12571"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01003.x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2017.08.010"},{"issue":"10","key":"e_1_2_10_49_1","first-page":"e029826","article-title":"Short implants (<\/=6 mm) versus longer implants with sinus floor elevation in atrophic posterior maxilla: A systematic review and meta\u2010analysis","volume":"9","author":"Yan Q.","year":"2019","journal-title":"British Medical Journal Open"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518755719"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.7.406"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.13781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/clr.13781","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.13781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T03:51:51Z","timestamp":1699069911000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.13781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,14]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/clr.13781"],"URL":"https:\/\/doi.org\/10.1111\/clr.13781","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,14]]},"assertion":[{"value":"2021-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}