{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:21:00Z","timestamp":1790828460386,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"S21","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the present systematic literature review was to determine whether long\u2010term treatment results with single\u2010tooth implants may differ depending on the timing of implant placement in relation to tooth extraction (immediate IP\/early EP\/delayed DP) and the timing of prosthetic loading (immediate IL\/early EL\/delayed DL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Electronic and manual searches were performed to identify studies reporting on long\u2010term results (survival rate and\/or marginal bone resorption after \u22653\u00a0years) of maxillary single\u2010tooth implants in the aesthetic zone using defined placement and loading protocols. Comparative trials were subjected to meta\u2010analyses whilst data from single\u2010arm studies were pooled to evaluate differences between timing protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 7 controlled trials were considered for meta\u2010analyses: immediate loading was compared to delayed loading in 3\u00a0studies on immediate placement (IPIL vs. IPDL, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.306) and in 2\u00a0studies on delayed placement (DPIL vs. DPDL, <jats:italic>p<\/jats:italic>\u00a0=\u00a01.000) whilst 2\u00a0studies compared early versus delayed placement with delayed loading (EPDL vs. DPDL, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.600), however, without significant differences. Pooled data analysis of 29\u00a0studies (965 implants) did not show differences between timing of placement or loading as well as marginal bone remodelling. No impact of the one abutment \u2013 one time concept, flap design and simultaneous bone or soft tissue augmentation could be established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Insufficient data are available for meta\u2010analytic comparison of all combinations of implant placement and loading protocols.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13838","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T12:59:44Z","timestamp":1634389184000},"page":"56-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Long\u2010term outcomes of maxillary single\u2010tooth implants in relation to timing protocols of implant placement and loading: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2617-0353","authenticated-orcid":false,"given":"Bernhard","family":"Pommer","sequence":"first","affiliation":[{"name":"Academy for Oral Implantology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Danzinger","sequence":"additional","affiliation":[{"name":"Academy for Oral Implantology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loise","family":"Leite Aiquel","sequence":"additional","affiliation":[{"name":"Division of Oral Surgery and Orthodontics Department of Dental Medicine &amp; Oral Health Medical University of Graz  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2334-4688","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Pitta","sequence":"additional","affiliation":[{"name":"Division of Fixed Prosthodontics and Biomaterials University Clinics for Dental Medicine University of Geneva  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-5069","authenticated-orcid":false,"given":"Robert","family":"Haas","sequence":"additional","affiliation":[{"name":"Academy for Oral Implantology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13125"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12487"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01911.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-11-00254"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g4.1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00029"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080071"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12336"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12134"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2019.08.004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12635"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12295"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517737755"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g3.3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40902-019-0216-2"},{"key":"e_1_2_9_17_1","first-page":"791","article-title":"Three\u2010year evaluation of single\u2010tooth implants restored 3 weeks after 1\u2010stage surgery","volume":"22","author":"Cooper L. 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