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Individuals were randomly assigned to test group (PBMT, <jats:italic>n<\/jats:italic>\u00a0=\u00a022) or control group (placebo, <jats:italic>n<\/jats:italic>\u00a0=\u00a022) applied immediately after surgery, 24 and 48\u00a0h after. Demographic, surgical\u2010related and psychosocial variables possibly associated with treatment response were collected. The primary outcome was postoperative pain at the donor site evaluated using Visual Analog Scale (VAS) immediately after surgery and 6, 24, 48 and 72\u00a0h after. Secondary outcomes include medication consumption, patient\u2010reported outcome measures (PROMs) and percentage of wound closure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intragroup analysis showed no differences in VASLOG means for placebo group throughout the study (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05), whereas a significant difference in PBMT group at 6\u00a0h, 24\u00a0h, 48\u00a0h and 72\u00a0h (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) were observed. Postoperative rescue analgesic requirement was significantly higher in the placebo group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). The number needed to treat(NNT) was 2.43. PBMT group reported significant better function related to sleeping, going to work\/school and daily routine activities, less restriction to mouth opening, chewing and food consumption, less swelling and bleeding (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), mainly in the first 48\u00a0h. PBMT group presented a significantly higher palatal wound closure at 7\u00a0days compared to placebo group (33.41 vs. 21.20 respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.024) after adjustment for confounding. No adverse effects were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Photobiomodulation therapy accelerated the pain resolution time and palatal closure, decreased rescue medication consumption and significantly improved patient satisfaction in the postoperative period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13923","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T17:59:35Z","timestamp":1647712775000},"page":"622-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Minimizing patient morbidity after free gingival graft harvesting:A triple\u2010blind randomized\u2010controlled clinical trial"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7310-2767","authenticated-orcid":false,"given":"Fernando Valentim","family":"Bitencourt","sequence":"first","affiliation":[{"name":"Department of Dentistry and Oral Health\u2014Section for Periodontology Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-7235","authenticated-orcid":false,"given":"Silvia","family":"Cardoso De David","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry\u2014Periodontology Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-724X","authenticated-orcid":false,"given":"Jasper da Silva","family":"Schutz","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry\u2014Periodontology Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-6161","authenticated-orcid":false,"given":"Alfredo","family":"Otto Kirst Neto","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry\u2014Periodontology Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4033-8431","authenticated-orcid":false,"given":"Fernanda","family":"Visioli","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry\u2014Oral Pathology Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-3822","authenticated-orcid":false,"given":"Tiago","family":"Fiorini","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry\u2014Periodontology Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190\u20109622(97)70325\u20106"},{"issue":"3","key":"e_1_2_11_3_1","first-page":"138","article-title":"Effect of nanohydroxyapatite associated with photobiomodulation in the control of dentin hypersensitivity: A randomized, double\u2010blind, placebo\u2010controlled clinical trial","volume":"33","author":"Alencar C. 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