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Secondly, a 10\u2010patient, prospective, randomized, controlled trial was performed to compare BCP<jats:sub>N<\/jats:sub> to ABG in MSFA with two\u2010stage implant placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pre\u2010clinical study demonstrated that both BCP<jats:sub>N<\/jats:sub> and BCP<jats:sub>G<\/jats:sub> were highly biocompatible, supported bony ingrowth with direct bone apposition against the material, and exhibited bone formation as early as 3\u2009weeks post\u2010implantation. However, BCP<jats:sub>N<\/jats:sub> demonstrated significantly more bone formation than BCP<jats:sub>G<\/jats:sub> at the study endpoint of 12\u2009weeks. Only BCP<jats:sub>N<\/jats:sub> reached an equivalent amount of bone formation in the available space and a greater proportion of calcified material (bone\u00a0+\u2009graft material) in the maxillary sinus compared to the \u201cgold standard\u201d ABG after 12\u2009weeks. These results were validated in a small prospective clinical study, in which BCP<jats:sub>N<\/jats:sub> was found comparable to ABG in implant stability, bone height, new bone formation in trephine core biopsies, and overall clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This translational work demonstrates that osteoinductive calcium phosphates are promising bone graft substitutes for MSFA, whereas their bone\u2010forming potential depends on the design of their surface features.<\/jats:p><jats:p>Netherlands Trial Register, NL6436.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14028","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T12:21:23Z","timestamp":1673871683000},"page":"177-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Osteoinductive calcium phosphate with submicron topography as bone graft substitute for maxillary sinus floor augmentation: A translational study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2018-4041","authenticated-orcid":false,"given":"Lukas A.","family":"van Dijk","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Utrecht  Utrecht the Netherlands"},{"name":"Regenerative Medicine Center Utrecht  Utrecht the Netherlands"},{"name":"Kuros Biosciences BV  Bilthoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-4559","authenticated-orcid":false,"given":"Nard G.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke J.","family":"Nurmohamed","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvick S. 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