{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:29:07Z","timestamp":1793402947185,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to systematically analyze the influence of smoking on the incidence of peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The search was performed in the National Library of Medicine (MEDLINE\u2010PubMed), SCOPUS, EMBASE, and ISI Web of Science databases (finished on November 30, 2022). Systematic review and meta\u2010analysis were conducted according to PRISMA statement. Prospective cohort studies that evaluate the incidence of peri\u2010implantitis in smokers and non\u2010smokers were included. Two authors independently searched for eligible studies, screened titles, and abstracts, did the full\u2010text analysis, extracted data, and performed the risk\u2010of\u2010bias assessment. The results were summarized through random\u2010effects meta\u2010analyses. The GRADE method was used to determine the certainty of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 7 studies with 702 patients and 1959 implants were included for analysis. The meta\u2010analysis revealed a significant difference between smokers and non\u2010smokers for the risk of peri\u2010implantitis in the implant\u2010based (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001) and patient\u2010based analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003). A strong association between smoking and the risk for peri\u2010implantitis was verified at the implant level (RR: 2.04, 95% CI: 1.46\u20131.85) and the patient level (RR: 2.79, 95% CI: 1.42\u20135.50).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Moderate certainty evidence suggests that smoking is associated with peri\u2010implantitis compared to non\u2010smoking at the patient and implant levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.14066","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T10:08:32Z","timestamp":1679306912000},"page":"543-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The influence of smoking on the incidence of peri\u2010implantitis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9249-4540","authenticated-orcid":false,"given":"Isabella Neme Ribeiro dos","family":"Reis","sequence":"first","affiliation":[{"name":"Department of Stomatology, Division of Periodontics, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-1817","authenticated-orcid":false,"given":"Guilherme Castro Lima Silva","family":"do Amaral","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Division of Periodontics, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9689-4074","authenticated-orcid":false,"given":"Mohamed Ahmed","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Division of Periodontics, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5905-5079","authenticated-orcid":false,"given":"Cristina Cunha","family":"Villar","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Division of Periodontics, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5669-912X","authenticated-orcid":false,"given":"Giuseppe Alexandre","family":"Romito","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Division of Periodontics, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9562-0610","authenticated-orcid":false,"given":"Rubens","family":"Spin\u2010Neto","sequence":"additional","affiliation":[{"name":"Department of Dentistry and Oral Health, Section for Oral Radiology, School of Dentistry Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4181-3975","authenticated-orcid":false,"given":"Claudio Mendes","family":"Pannuti","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Division of Periodontics, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12557"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12575"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100757.2002.290109.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12664"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13062"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2014.09.018"},{"issue":"6","key":"e_1_2_9_8_1","first-page":"609","article-title":"The association between the failure of dental implants and cigarette smoking","volume":"8","author":"Bain C. 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