{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:50:57Z","timestamp":1791917457152,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Intrinsic apoptosis, which is regulated by Bcl\u20102 family proteins, has an important role in chronic inflammatory diseases. The aim of the study was to identify the tissue levels and ratios of anti\u2010 and pro\u2010apoptotic Bcl\u20102 family proteins in peri\u2010implant diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010three individuals with peri\u2010implant mucositis, 25 individuals with peri\u2010implantitis, and 24 controls were included. The following clinical parameters were recorded: keratinized mucosa width, modified bleeding index, probing depth, modified plaque index, modified gingival index, and keratinized tissue thickness. Marginal alveolar bone assessments were performed by a software program. Granulation tissues were collected during treatments of peri\u2010implant diseases. The control tissue samples were collected during the second stage of implant surgery. The tissue levels of Bcl\u20102 family pro\u2010apoptotic (Bak, Bax, active caspase\u20103) and anti\u2010apoptotic (Bcl\u20102, Bcl\u2010xL, Mcl\u20101) proteins were determined by multiplex immunoassay method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pro\u2010apoptotic proteins; Bak, Bax and anti\u2010apoptotic proteins Bcl\u20102, Bcl\u2010xL, Mcl\u20101 were detected significantly higher in controls compared with patients with peri\u2010implant mucositis and peri\u2010implantitis (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), respectively. The higher active caspase\u20103 levels were also detected in controls in comparison with peri\u2010implant mucositis (<jats:italic>p<\/jats:italic>\u2009=\u2009.018) and peri\u2010implantitis (<jats:italic>p<\/jats:italic>\u2009=\u2009.005). Anti\u2010apoptotic: pro\u2010apoptotic protein ratios (Bcl\u20102:Bax, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; Bcl\u20102:Bak, <jats:italic>p<\/jats:italic>\u2009=\u2009.01; Bcl\u2010xL: Bax, <jats:italic>p<\/jats:italic>\u2009=\u2009.006, Bcl\u2010xL:Bak, <jats:italic>p<\/jats:italic>\u2009=\u2009.011; Mcl\u20101:Bak, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) were significantly increased in diseased groups. A positive correlation was demonstrated between clinical variables and anti\u2010apoptotic: pro\u2010apoptotic ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate dysregulation of the Bcl\u20102 family proteins in peri\u2010implant diseases. This unregulated response may disturb the homeostasis of peri\u2010implant tissue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14067","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T08:49:14Z","timestamp":1681116554000},"page":"582-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Anti\u2010Apoptotic and Pro\u2010Apoptotic Bcl\u20102 Family Proteins in Peri\u2010Implant Diseases"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2576-0885","authenticated-orcid":false,"given":"Dogukan","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Sakarya University  Sakarya Turkey"},{"name":"Department of Periodontology Institute of Dentistry, University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8545-6821","authenticated-orcid":false,"given":"Mervi","family":"G\u00fcrsoy","sequence":"additional","affiliation":[{"name":"Department of Periodontology Institute of Dentistry, University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1225-5751","authenticated-orcid":false,"given":"Ulvi Kahraman","family":"G\u00fcrsoy","sequence":"additional","affiliation":[{"name":"Department of Periodontology Institute of Dentistry, University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201108081"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010019\u20100173\u20108"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2004.01072.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.481"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166217"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2015.46"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.01.008"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00983"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13925"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12422"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.08.011"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3479"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u2010051x.2003.00350.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21\u20100423"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.04.024"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1385\/0\u201089603\u2010126\u20108:25"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.1.35"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.130718"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.4.557"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12723"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.167378"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13416"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12892"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068983"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020162"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e31818c4a24"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.691013"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.01.036"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18475"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160144"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u2010302x.1987.tb00298.x"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12791"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.06.001"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12479"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13227"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030537"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13928"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729\u2010021\u201000388\u2010x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20\u20100124"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516667484"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13827"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12954"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12417"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15\u2010272997"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041\u20101014.2012.00648.x"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2022.101659"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104926"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010017\u20101116\u20105"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12810"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2308"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201098007\u20107"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.14067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T09:28:52Z","timestamp":1692437332000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.14067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,10]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/clr.14067"],"URL":"https:\/\/doi.org\/10.1111\/clr.14067","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,10]]},"assertion":[{"value":"2023-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}