{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T12:26:00Z","timestamp":1772886360396,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the sequential osseointegration of a novel titanium implant system based on a 3D printing technology in comparison with conventional titanium implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Two novel titanium implants based on 3D printing were tested in the mandible of eight Beagle dogs. As a control, two different commercially available titanium implants were used. The implants were staged to accommodate healing periods of 2 and 6\u2009weeks. The primary outcome variable was bone\u2010to\u2010implant contact (BIC) in non\u2010decalcified tissue sections and micro\u2010CT analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histomorphometrically, the proportions of tissues adjacent to the implant surfaces were similar for all implants, whereas the BIC percentage of new mineralized bone was greater for the control implants after both 2 and 6\u2009weeks (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Micro\u2010CT analysis revealed increasing osseous volume and BIC from 2 to 6\u2009weeks. In contrast to the histomorphometry, the BIC evaluation with the micro\u2010CT data revealed a significantly higher BIC for the two test implants compared with controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The analysis of the total implant surface area disclosed a value that was approximately double as high for the test compared to the control implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel titanium implant system based on 3D printing yielded values for osseointegration that were adequate and satisfactory. The higher percentage of new mineralized bone in the control implants is explained by the fact of a completely different three\u2010dimensional surface area.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14072","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T18:24:38Z","timestamp":1682101478000},"page":"627-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sequential osseointegration of a novel implant system based on <scp>3D<\/scp> printing in comparison with conventional titanium implants"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6938-9611","authenticated-orcid":false,"given":"Niklaus P.","family":"Lang","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"},{"name":"Department of Cranio\u2010Maxillofacial Surgery University Hospital, University of 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