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The hypothesis is that implant failure is higher in these patients, when compared to patients receiving penicillin. To test this hypothesis, a systematic review and meta\u2010analysis was undertaken and a protocol for delabeling penicillin allergic patients was presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A systematic review was undertaken by searching across three different databases, namely PubMed, Scopus and Web of Science.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 572 results, four studies were eligible to be included. Fixed\u2010effects meta\u2010analysis showed a higher number of failed implants in patients who were administered clindamycin, because of a self\u2010reported allergy to penicillin. Results showed that these patients are over three times more likely (OR\u2009=\u20093.30, 95% C.I. 2.58\u20134.22,<jats:italic>p<\/jats:italic>\u2010value\u2009&lt;\u2009.00001) to undergo implant failure with an average cumulative proportion of 11.0% (95% C.I. 3.5\u201322.0%) versus 3.8% (95% C.I. 1.2\u20137.7%) of patients not requiring clindamycin and administered amoxicillin. A protocol for penicillin allergy delabeling is proposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Current evidence is still limited and based on retrospective observational studies, it is difficult to state if penicillin allergy, clindamycin administration or a combination of both is responsible for the current trends and reported findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14073","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T07:29:43Z","timestamp":1682580583000},"page":"651-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Self\u2010reported allergy to penicillin and clindamycin administration may be risk factors for dental implant failure: A systematic review, meta\u2010analysis and delabeling 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