{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:39:04Z","timestamp":1792737544129,"version":"4.5.0"},"reference-count":0,"publisher":"Wiley","issue":"S26","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2023,9]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n The aim of Working Group 3 was to address the influence of both material\u2010 and anti\u2010resorptive drug\u2010 related factors on clinical and biological outcomes and complications in implant dentistry. Focused questions were addressed on (a) implant materials other than titanium (alloy)s, (b) transmucosal abutment materials and (c) medications affecting bone metabolism were addressed.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n Three systematic reviews formed the basis for discussion in Group 3. Consensus statements and clinical recommendations were formulated by group consensus based on the findings of the systematic reviews. Patient perspectives and recommendations for future research were also conveyed. These were then presented and accepted following further discussion and modifications as required by the plenary.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Zirconia is a valid alternative to titanium as material for implant and transmucosal components, allowing soft and hard tissue integration with clinical outcomes\u2014identified by implant survival, marginal bone loss and peri\u2010implant probing depths\u2014up to 5\u2010years comparable to titatnium. However, most of the evidence for zirconia implants is based on 1\u2010piece implants limiting the indication range. Furthermore, based on expert opinion, zirconia transmucosal components might be preferred in the esthetic zone. In patients receiving low\u2010dose bisphosphonate therapy, the rate of early implant failure is not increased, while the long\u2010term effects remain poorly studied. Although it has not been sufficiently addressed, similar outcomes can be expected with low\u2010dose denosumab. A drug holiday is not recommended when considering implant placement in patients treated with low\u2010dose ARD. However, the specific therapeutic window, the cumulative dose and the administration time should be considered. Access to peri\u2010implant supportive care is mandatory to prevent peri\u2010implantitis\u2010related medication\u2010related osteonecrosis of the jaw (MRONJ) or implant\u2010related sequestra (IRS). In patients receiving low\u2010dose anti\u2010resorptive drugs (ARD) therapy, the risk of complications related to implant placement is high, and implant procedures in this specific population should be strictly treated in a comprehensive multidisciplinary center. Finally, healthy dental implants should not be removed before low or high\u2010dose ARD.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Zirconia implants can be an alternative to titanium implants in selected indications. However, the current state of evidence remains limited, especially for 2\u2010piece implant designs. Administration of low\u2010dose ARD did not show any negative impact on early implant outcomes, but careful follow\u2010up and supportive care is recommended in order to prevent peri\u2010implant MRONJ and IRS. Implant placement in high\u2010dose patients must be strictly considered in a comprehensive multidisciplinary center.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/clr.14135","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:31:45Z","timestamp":1695713505000},"page":"169-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Group 3 ITI Consensus Report: Materials and antiresorptive drug\u2010associated outcomes in implant dentistry"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8665-5803","authenticated-orcid":false,"given":"Bilal","family":"Al\u2010Nawas","sequence":"first","affiliation":[{"name":"Department for Oral and Maxillofacial Surgery, Plastic Surgery University Medical Center of the J. Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1018-2544","authenticated-orcid":false,"given":"France","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Oro\u2010dental and Implant Surgery, CHU of Li\u00e8ge Li\u00e8ge University Li\u00e8ge Belgium"},{"name":"Dental Biomaterials Research Unit Li\u00e8ge University Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne Werner M\u00f8ller","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7773-8957","authenticated-orcid":false,"given":"Michael M.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Oral Health & Medicine, University Center for Dental Medicine Basel UZB University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gahlert","sequence":"additional","affiliation":[{"name":"Private Dental Clinic PD Dr. Gahlert & PD Dr. Roehling Munich Germany"},{"name":"Clinic for Oral and Cranio\u2010Maxillofacial Surgery, Hightech Research Center, University Hospital Basel University of Basel Basel Switzerland"},{"name":"Sigmund Freud Private University Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5902-4520","authenticated-orcid":false,"given":"Asbjorn","family":"Jokstad","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences UiT, The Arctic University of Norway Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junho","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Dentistry Kyung Hee University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9620-4814","authenticated-orcid":false,"given":"Yong\u2010Dae","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Dentistry Kyung Hee University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9662-8238","authenticated-orcid":false,"given":"Isabelle","family":"Laleman","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Oro\u2010dental and Implant Surgery, CHU of Li\u00e8ge Li\u00e8ge University Li\u00e8ge Belgium"},{"name":"Dental Biomaterials Research Unit Li\u00e8ge University Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Oteri","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Roehling","sequence":"additional","affiliation":[{"name":"Private Dental Clinic PD Dr. Gahlert & PD Dr. Roehling Munich Germany"},{"name":"Clinic for Oral and Cranio\u2010Maxillofacial Surgery, Hightech Research Center, University Hospital Basel University of Basel Basel Switzerland"},{"name":"Clinic for Oral and Cranio\u2010Maxillofacial Surgery, Kantonsspital Aarau Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1859-943X","authenticated-orcid":false,"given":"Eik","family":"Schiegnitz","sequence":"additional","affiliation":[{"name":"Head Division of Implantology, Department of Oral and Maxillofacial Surgery, Plastic Surgery University Medical Centre of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Takeda","sequence":"additional","affiliation":[{"name":"Private Dental Clinic Takeda Dental Clinic Tokyo Japan"},{"name":"Department of Oral and Maxillofacial Implantology Tokyo Dental College Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0709-114X","authenticated-orcid":false,"given":"Hendrik","family":"Terheyden","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery Helios Kliniken Kassel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,26]]},"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.14135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T07:17:08Z","timestamp":1698909428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.14135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":0,"journal-issue":{"issue":"S26","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/clr.14135"],"URL":"https:\/\/doi.org\/10.1111\/clr.14135","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"2023-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}