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The objective of this study was to evaluate the efficacy of PA in single dental implant surgeries (SDIS), seeking to identify among the etoricoxib (ETOR), ibuprofen (IBU), nimesulide (NIME), and acetaminophen (ACETA)], which one has the higher efficacy effectiveness in relieving postoperative pain and reducing the use of rescue medication compared to placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this triple\u2010blind, parallel, randomized controlled clinical trial, 135 individuals with a mean age of 57.6\u2009years (\u00b111.7), both genders, were randomly divided into five groups according to the test drug: I\u2014PLACEBO; II\u2014IBU (600\u2009mg); III\u2014NIME (100\u2009mg); IV\u2014ACETA (750\u2009mg); and V\u2014ETOR (90\u2009mg). The occurrence, duration, and intensity of pain were analyzed using the Chi\u2010square, Fisher's exact and ANOVA tests, and the generalized estimating equation models, when appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Test drugs provided a reduction in postoperative pain scores and lower use of rescue medication when compared to placebo. The ETOR group presented significantly lower pain scores, when compared to other active treatments. The IBU group showed the highest mean number of rescue medication used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All test drugs provided a beneficial preemptive effect demonstrated by the reduced postoperative pain and reduced use of rescue medication. The ETOR group presented lower pain scores, and the IBU group showed the highest mean number of rescue medication used among the test groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14170","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:44:50Z","timestamp":1693212290000},"page":"1299-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preemptive effects of etoricoxib, acetaminophen, nimesulide, and ibuprofen on postoperative pain management after single\u2010implant surgery: A randomized clinical trial"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0176-0741","authenticated-orcid":false,"given":"Gustavo Henrique","family":"Mattos\u2010Pereira","sequence":"first","affiliation":[{"name":"Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4343-3845","authenticated-orcid":false,"given":"Rafael Paschoal","family":"Esteves\u2010Lima","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1517-5842","authenticated-orcid":false,"given":"Lu\u00eds Ot\u00e1vio Miranda","family":"Cota","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-2262","authenticated-orcid":false,"given":"Rachel","family":"Alvarenga\u2010Brant","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7687-1238","authenticated-orcid":false,"given":"Fernando Oliveira","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109592.2008.02764.x"},{"key":"e_1_2_9_3_1","unstructured":"ANVISA. 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