{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:54:48Z","timestamp":1791284088224,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The goal of this extension study was to compare the 10\u2010year outcome of 3.3\u2009mm diameter titanium\u2013zirconium (TiZr) or grade IV titanium (Ti) implants in mandibular implant\u2010overdentures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study is the 10\u2010year follow\u2010up from a randomised, controlled, double\u2010blind, split\u2010mouth multicentre clinical trial. Patients with edentulous mandibles had received two implants in the interforaminal region (bone\u2010level, diameter 3.3\u2009mm, microrough surface), one of TiZr (test) and one of Ti (control). Implant survival and success, plaque and sulcus bleeding indices, probing pocket depth, gingival margin, clinical attachment level and radiographic crestal bone levels were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty of 91 patients with implants were available for the 10\u2010year examination and 36 patients were valid for the intent\u2010to\u2010treat (ITT) analysis. The implant success rate was calculated as 94.6% and 91.9% for the TiZr implants and the Ti implants respectively. Four implants were lost (TiZr\u2009=\u20091; Ti\u2009=\u20093) in the entire study period. Kaplan\u2013Meier survival analyses estimated 10\u2010\u2009year implant survival rate for TiZr to 98.9% and Ti 95.8%.The mean of total and functional crestal bone loss was 1.49\u2009mm (\u00b11.37\u2009mm) and 0.82\u2009mm (\u00b11.09\u2009mm) in the TiZr group and 1.56\u2009mm (\u00b11.34\u2009mm) and 0.85\u2009mm (\u00b11.16\u2009mm) in the Ti group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This split\u2010mouth design RCT on mandibular implant\u2010overdentures evidenced, bearing in mind its follow\u2010up time\u2010related reduced cohort size, high 10\u2010year implant success\u2010 and survival rates. These results confirm TiZr as well\u2010suited implant material for realising small\u2010diameter implants.<\/jats:p><jats:p>Registered on <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>: NCT01878331.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14199","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T10:24:30Z","timestamp":1699525470000},"page":"77-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Small\u2010diameter titanium grade IV and titanium\u2013zirconium implants in edentulous mandibles: Ten\u2010year results from a double\u2010blind, randomised controlled split\u2010mouth core\u2010trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3981-0134","authenticated-orcid":false,"given":"Frauke","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Division of Gerodontology and Removable Prosthodontics University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Al\u2010Nawas","sequence":"additional","affiliation":[{"name":"Johannes\u2010Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7412-0596","authenticated-orcid":false,"given":"Stefano","family":"Storelli","sequence":"additional","affiliation":[{"name":"Dental Clinic, San Paolo Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Quirynen","sequence":"additional","affiliation":[{"name":"School of Dentistry Catholic University Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hicklin","sequence":"additional","affiliation":[{"name":"Clinic of Preventive Dentistry, Periodontology and Cariology, Center for Dental Medicine University of Zurich  Zurich Switzerland"},{"name":"Clinic of General, Special Care and Geriatric Dentistry, Center for Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Castro\u2010Laza","sequence":"additional","affiliation":[{"name":"University of Regensburg Clinic  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Bassetti","sequence":"additional","affiliation":[{"name":"Clinic for Oral and Maxillofacial Surgery Cantonal Hospital Lucerne  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-576X","authenticated-orcid":false,"given":"Murali","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Division of Gerodontology and Removable Prosthodontics University of Geneva  Geneva Switzerland"},{"name":"Clinic of General, Special Care and Geriatric Dentistry, Center for Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Roxolid Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12793"},{"key":"e_1_2_9_3_1","first-page":"446","article-title":"A modified short version of the oral health impact profile for assessing health\u2010related quality of life in edentulous adults","volume":"15","author":"Allen F.","year":"2002","journal-title":"The International Journal of Prosthodontics"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2010.00324.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-13-00149"},{"key":"e_1_2_9_6_1","first-page":"294","article-title":"Use of narrow\u2010diameter implants in the posterior jaw: A systematic review","volume":"24","author":"Assaf A.","year":"2015","journal-title":"Implant Dentistry"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12205"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12772"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12624"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1998.tb00125.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.00988.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1990.010105.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107BOR-2016.vol30.0102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02264.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514563077"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515608832"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/285684"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2004.tb00035.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12822"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2002.00003.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj10050083"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12947"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.6927"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01026.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12061"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12814"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2018.11.011"},{"key":"e_1_2_9_28_1","first-page":"139","article-title":"Oral health of individuals aged 3\u201380\u2009years in J\u00f6nk\u00f6ping, Sweden during 30\u2009years (1973\u20132003). II. Review of clinical and radiographic findings","volume":"29","author":"Hugoson A.","year":"2005","journal-title":"Swedish Dental Journal"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2020.11403"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12369"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12305"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12175"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820290805"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2010.00329.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12523"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2017.06.004"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/19424396.2008.12221491"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00182.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01118.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12585"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1987.tb00298.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/ger.12083"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-015-0107-6"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513509630"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02213.x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.1994.tb00096.x"},{"key":"e_1_2_9_47_1","first-page":"69","article-title":"Oral health of individuals aged 3\u201080\u2009years in J\u00f6nk\u00f6ping, Sweden during 40\u2009years (1973\u20102013). II. Review of clinical and radiographic findings","volume":"39","author":"Norderyd O.","year":"2015","journal-title":"Swedish Dental Journal"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12756"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g4.3"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12068"},{"issue":"2","key":"e_1_2_9_51_1","first-page":"S91","article-title":"Patients' preferences towards minimally invasive treatment alternatives for implant rehabilitation of edentulous jaws","volume":"7","author":"Pommer B.","year":"2014","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12367"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2010.02143.x"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.7133"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516667484"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v023a21"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12166"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g4.4"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02410.x"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14068"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0301-5661.2004.00131.x"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100737"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2011.08.017"},{"key":"e_1_2_9_64_1","first-page":"365","article-title":"Long\u2010term results of mandibular implants supporting an overdenture: Implant survival, failures, and crestal bone level changes","volume":"26","author":"Ueda T.","year":"2011","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01915.x"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2921"},{"key":"e_1_2_9_67_1","first-page":"483","article-title":"Choosing or refusing oral implants: A prospective study of edentulous volunteers for a clinical trial","volume":"18","author":"Walton J. N.","year":"2005","journal-title":"The International Journal of Prosthodontics"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12141"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12657"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140390"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000668"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.14199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T04:08:12Z","timestamp":1706846892000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.14199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,9]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/clr.14199"],"URL":"https:\/\/doi.org\/10.1111\/clr.14199","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,9]]},"assertion":[{"value":"2023-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}