{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T13:15:25Z","timestamp":1770729325672,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess in a prospective randomized trial two phycogenic bone substitutes\u2014biphasic calcium phosphate (BCP) versus almost pure hydroxyapatite (HA)\u2014for their volume stability and clinical implications after sinus floor elevation (SFE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty patients requiring lateral\u2010window SFE 6\u2009months prior to implant surgery were randomized to a BCP or HA group. As primary outcome, the grafts were analyzed for volume stability, using four cone\u2010beam computed tomography scans obtained immediately\/6\/12\/24\u2009months after SFE. Secondary outcomes were implant survivval, success, periotest values, oral\u2010health\u2010related quality of life (OHIP\u2010G14), and pain (VAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Kolmogorov\u2013Smirnov goodness\u2010of\u2010fit test revealed normal distribution of samples (<jats:italic>p<\/jats:italic>\u2009=\u2009.200). At 6\/12\/24\u2009months, the augmented volumes decreased to 96\/92\/90% (HA) or 99\/96\/96% (BCP). Volume changes were significantly a factor of time (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; generalized linear model with repeated measures) and reached significantly lower values in HA group (<jats:italic>p<\/jats:italic>\u2009=\u2009.018). Significant intergroup difference in volume losses was notable at 24\u2009months (<jats:italic>p<\/jats:italic>\u2009=\u2009.021; <jats:italic>t<\/jats:italic>\u2010test for independent samples). Periotest values decreased from \u22123\/\u22124.1 (HA\/BCP) after implant placement to \u22126.3\/\u22124.5 (HA\/BCP) after 6\u2009months. OHIP scores diverged at 2\u2009months (HA: 9.5; BCP: 5.2) and largely resolved by 24\u2009months (HA: 1.3; BCP: 1.9). VAS scores were comparable, 2.2 at 1\u2009week after SFE being their highest mean level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After 2\u2009years, both groups experienced no biological or technical complications, demonstrating a consistent healing trajectory without notable symptoms. Although no significant differences were observed in implant stability and survival, BCP demonstrated higher volume stability than HA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14209","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T19:14:16Z","timestamp":1700680456000},"page":"155-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A randomized clinical trial of phycogenic materials for sinus grafting with hydroxyapatite versus biphasic calcium phosphate: 2\u2009years clinical outcomes"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8858-6349","authenticated-orcid":false,"given":"Alwin","family":"Sokolowski","sequence":"first","affiliation":[{"name":"Division of Restorative Dentistry, Periodontology and Prosthodontics, Department of Dental Medicine and Oral Health Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7881-9812","authenticated-orcid":false,"given":"Kerstin","family":"Theisen","sequence":"additional","affiliation":[{"name":"Division of Restorative Dentistry, Periodontology and Prosthodontics, Department of Dental Medicine and Oral Health Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behrouz","family":"Arefnia","sequence":"additional","affiliation":[{"name":"Division of Restorative Dentistry, Periodontology and Prosthodontics, Department of Dental Medicine and Oral Health Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4469-8335","authenticated-orcid":false,"given":"Michael","family":"Payer","sequence":"additional","affiliation":[{"name":"Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-0220","authenticated-orcid":false,"given":"Martin","family":"Lorenzoni","sequence":"additional","affiliation":[{"name":"Division of Restorative Dentistry, Periodontology and Prosthodontics, Department of Dental Medicine and Oral Health Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9553-7112","authenticated-orcid":false,"given":"Armin","family":"Sokolowski","sequence":"additional","affiliation":[{"name":"Division of Restorative Dentistry, Periodontology and Prosthodontics, Department of Dental Medicine and Oral Health Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12223704"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.55113"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.7.911"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070255"},{"issue":"6","key":"e_1_2_12_6_1","first-page":"579","article-title":"Measuring the efficacy of rhBMP\u20102 to regenerate bone: A radiographic study using a commercially available software program","volume":"24","author":"Bianchi J.","year":"2004","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553\u20102712.2001.tb01132.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0278\u20102391(97)90185\u20103"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2008.01573.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050138"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.1982.tb00172.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.08.020"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100501.2001.120514.x"},{"key":"e_1_2_12_15_1","volume-title":"Registration of dental CT images for jawbone implant resorption analysis","author":"Grbic S.","year":"2008"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100501.1998.090206.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2002.30576"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100757.2008.00251.x"},{"key":"e_1_2_12_19_1","first-page":"39","article-title":"History of treated periodontitis and smoking as risks for implant therapy","volume":"24","author":"Heitz\u2010Mayfield L. 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