{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:36:19Z","timestamp":1778175379618,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52171234"],"award-info":[{"award-number":["52171234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFE0101100 and 2021YFC2400703"],"award-info":[{"award-number":["2019YFE0101100 and 2021YFC2400703"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study bone healing of two\u2010wall bone defects after alveolar ridge preservation using mineralized dentin matrix.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>After distal roots extraction of second and fourth premolars (P2, P4) on one lateral mandible in 12 beagles, two\u2010wall bone defects (5\u2009\u00d7\u20095\u2009\u00d7\u20095\u2009mm) were surgically created distally to the remaining mesial roots of P2 and P4. A total of 24 sites were randomly allocated to three groups (implant material\u2010 time of execution): mineralized dentin matrix (MDM)\u20103\u2009m (MDM\u2009+\u2009collagen membrane; 3\u2009months), MDM\u20106\u2009m (MDM particles\u2009+\u2009collagen membrane; 6\u2009months), and C\u20106\u2009m (collagen membrane only; 6\u2009months). Clinical, radiographic, digital, and histological examinations were performed 3 and 6\u2009months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The bone healing in MDM groups were better compared to Control group (volume of bone regenerated in total: 25.12\u2009mm<jats:sup>3<\/jats:sup> vs. 13.30\u2009mm<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u2009.046; trabecular volume\/total volume: 58.84% vs. 39.18%, <jats:italic>p<\/jats:italic>\u2009=\u2009.001; new bone formation rate: 44.13% vs. 31.88%, <jats:italic>p<\/jats:italic>\u2009=\u2009.047). Vertically, the radiological bone level of bone defect in MDM\u20106\u2009m group was higher than that in C\u20106\u2009m group (vertical height of bone defect: 1.55\u2009mm vs. 2.74\u2009mm, <jats:italic>p<\/jats:italic>\u2009=\u2009.018). Horizontally, no significant differences in buccolingual bone width were found between MDM and C groups at any time or at any level below the alveolar ridge. The percentages of remaining MDM were &lt;1% in both MDM\u20103\u2009m and MDM\u20106\u2009m groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MDM improved bone healing of two\u2010wall bone defects and might be considered as a socket fill material used following tooth extraction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14239","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T05:30:11Z","timestamp":1706592611000},"page":"407-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Alveolar ridge preservation of two\u2010wall bone defects using mineralized dentin matrix: An experimental pre\u2010clinical study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8486-867X","authenticated-orcid":false,"given":"Zi\u2010Yu","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6474-133X","authenticated-orcid":false,"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5857-2808","authenticated-orcid":false,"given":"Jian\u2010Min","family":"Han","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Department of Dental Materials Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-0153","authenticated-orcid":false,"given":"Bin\u2010Zhang","family":"Wu","sequence":"additional","affiliation":[{"name":"First Clinical Division Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5810-824X","authenticated-orcid":false,"given":"Chuan\u2010Bin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0642-5942","authenticated-orcid":false,"given":"Nian\u2010Hui","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102842.2010.02065.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13297"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12366"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2009.01854.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13057"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12469"},{"key":"e_1_2_11_8_1","first-page":"399","article-title":"Ridge preservation techniques to avoid invasive bone reconstruction: A systematic review and meta\u2010analysis: Naples consensus report working group C","volume":"12","author":"Barootchi S.","year":"2019","journal-title":"The International Journal of Oral Implantology"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100757.2000.2240113.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13722"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/app9051013"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12603"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13770\u2010022\u201000438\u20104"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.22197"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2012.02434.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12041"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13426"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.2.229"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2013.39.3.103"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147235"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13557"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12414"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2319\/121608\u2010639.1"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12911"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000713"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2010.00873.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.33236"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100016"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12885"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678\u20107757\u20102019\u20100148"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2007.01428.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/edt.12101"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366\u20106999.183430"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13765"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13371"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2005.090"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12579"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12977"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13197"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2010.01539.x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10278\u2010012\u20109562\u20107"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2011.02375.x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13791"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2011.02331.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2017.05.007"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010020\u201001250\u2010z"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2020.09.015"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20109969(67)90095\u20107"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.14239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T09:14:18Z","timestamp":1712567658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.14239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/clr.14239"],"URL":"https:\/\/doi.org\/10.1111\/clr.14239","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]},"assertion":[{"value":"2022-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}