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Studies with data from patients undergoing therapeutic approaches using agents for palatal healing after gingival graft harvesting were included. Data about postoperative pain, wound\u2010healing and postoperative complications reported for each agent were extracted. Three different tools were used for the risk of bias within studies evaluation (Murad tool for case series and case report, RoB 2.0 tool for randomized studies and ROBINS\u2010I tool for non\u2010randomized studies). A Bayesian random effects NMA was conducted for postoperative pain levels and wound healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty\u2010four publications were included in the systematic review (qualitative analysis), with 14 of these subjected to NMA (quantitative analysis). The summarized results from the qualitative and quantitative analysis showed that all wound\u2010healing agents evaluated promoted better pain control and wound healing compared to spontaneous healing and hemostatic sponges alone. The NMA outcomes reveal that leucocyte\u2010 and platelet\u2010rich fibrin (L\u2010PRF) was the most effective agent in reducing postoperative pain in all analyzed periods. Moreover, the L\u2010PRF seems to accelerate wound healing and reduce postoperative complications compared to other agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, the L\u2010PRF was the most effective agent in reducing postoperative pain, accelerating wound healing and reducing postoperative complications after harvesting soft tissue grafts from the palatal area.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.14241","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T02:25:31Z","timestamp":1707272731000},"page":"359-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Wound\u2010healing agents for palatal donor area: A network 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