{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:41:51Z","timestamp":1779205311098,"version":"3.51.4"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271003"],"award-info":[{"award-number":["82271003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2019728"],"award-info":[{"award-number":["BE2019728"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to synthesize zinc\u2010incorporated nanowires structure modified titanium implant surface (Zn\u2010NW\u2010Ti) and explore its superior osteogenic and antibacterial properties in\u00a0vitro and in\u00a0vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Zn\u2010NW\u2010Ti was synthesized via displacement reactions between zinc sulfate solutions and the titanium (Ti) surface, which was pretreated by hydrofluoric acid etching and hyperthermal alkalinization. The physicochemical properties of the Zn\u2010NW\u2010Ti surface were examined. Moreover, the biological effects of Zn\u2010NW\u2010Ti on MC3T3\u2010E1 cells and its antibacterial property against oral pathogenic bacteria (<jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Porphyromonas gingivalis<\/jats:italic>, and <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>) compared with sandblasted and acid\u2010etched Ti (SLA\u2010Ti) and nanowires modified Ti (NW\u2010Ti) surface were assessed. Zn\u2010NW\u2010Ti and SLA\u2010Ti modified implants were inserted into the anterior extraction socket of the rabbit mandible with or without exposure to the mixed bacterial solution (<jats:italic>S<\/jats:italic>. <jats:italic>aureus<\/jats:italic>, <jats:italic>P<\/jats:italic>. <jats:italic>gingivalis<\/jats:italic>, and <jats:italic>A<\/jats:italic>. <jats:italic>actinomycetemcomitans<\/jats:italic>) to investigate the osteointegration and antibacterial performance via radiographic and histomorphometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Zn\u2010NW\u2010Ti surface was successfully prepared. The resultant titanium surface appeared as a nanowires structure with hydrophilicity, from which zinc ions were released in an effective concentration range. The Zn\u2010NW\u2010Ti surface performed better in facilitating the adhesion, proliferation, and differentiation of MC3T3\u2010E1 cells while inhibiting the colonization of bacteria compared with SLA\u2010Ti and NW\u2010Ti surface. The Zn\u2010NW\u2010Ti implant exhibited enhanced osseointegration in\u00a0vivo, which was attributed to increased osteogenic activity and reduced bacterial\u2010induced inflammation compared with the SLA\u2010Ti implant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Zn\u2010incorporated nanowires structure modified titanium implant surface exhibited improvements in osteogenic and antibacterial properties, which optimized osteointegration in comparison with SLA titanium implant surface.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14242","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T06:10:09Z","timestamp":1707286209000},"page":"427-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Enhanced osteogenic and antibacterial properties of titanium implant surface modified with Zn\u2010incorporated nanowires: Preclinical in\u00a0vitro and in\u00a0vivo investigations"],"prefix":"10.1111","volume":"35","author":[{"given":"Zhe","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Oral Implantology Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Key Laboratory of Oral Diseases  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Key Laboratory of Oral Diseases  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing 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