{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:21:02Z","timestamp":1790828462429,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare immediate implant placement (IIP) with early implant placement (EIP) for single tooth replacement in the aesthetic area in terms of aesthetic, clinical, and patient\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Two independent reviewers conducted an electronic literature search in PubMed, Web of Science, Embase, and Cochrane databases as well as a manual search to identify eligible clinical studies up to February 2023. Randomized Controlled Trials (RCTs) comparing IIP with EIP were included for a qualitative and quantitative analysis. The primary outcome was vertical midfacial soft tissue change. Secondary outcomes were horizontal midfacial soft tissue change, vertical papillary change, pink esthetic score (PES), implant survival, buccal bone thickness, marginal bone level change, patient discomfort, chair time, and patient satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 1185 records, 6 RCTs were selected, reporting on 222 patients who received 222 single implants (IIP: 112 implants in 112 patients; EIP: 110 implants in 110 patients) in the anterior maxilla or mandible. Patients had a mean age ranging from 35.6 to 52.6\u2009years and were followed between 8 and 24\u2009months. Two RCTs showed some concerns, and four showed a high risk of bias. Four studies could be included in a meta\u2010analysis on the primary outcome and three only considered cases with an intact buccal bone wall. Meta\u2010analysis failed to demonstrate a significant difference in terms of vertical midfacial soft tissue change between IIP and EIP (mean difference: 0.31\u2009mm, 95% CI [\u22120.23; 0.86], <jats:italic>p<\/jats:italic>\u2009=\u2009.260; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200983%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). No significant differences were found for PES (standardized mean difference: 0.92, 95% CI [\u22120.23; 2.07], <jats:italic>p<\/jats:italic>\u2009=\u2009.120; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200989%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), implant survival (RR: 0.98, 95% CI [0.93, 1.03], <jats:italic>p<\/jats:italic>\u2009=\u2009.480; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%, <jats:italic>p<\/jats:italic>\u2009=\u2009.980), and marginal bone level change (mean difference: 0.03\u2009mm, 95% CI [\u22120.12, 0.17], <jats:italic>p<\/jats:italic>\u2009=\u2009.700; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%, <jats:italic>p<\/jats:italic>\u2009=\u2009.470). Insufficient data were available for meta\u2010analyses of other secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In low\u2010risk patients with an intact buccal bone wall, there seems to be no difference between IIP and EIP in terms of aesthetic and clinical outcomes. The strength of this conclusion is rated as low since studies showed an unclear or high risk of bias. In addition, state\u2010of\u2010the\u2010art therapy was only delivered in a minority of studies. Future RCTs should also provide data on patient\u2010reported outcomes since these have been underreported.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14261","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T10:15:15Z","timestamp":1711966515000},"page":"585-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Immediate versus early implant placement for single tooth replacement in the aesthetic area: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"35","author":[{"given":"Axelle","family":"Ickroth","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences, Department of Periodontology and Oral Implantology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1547-057X","authenticated-orcid":false,"given":"Lorenz","family":"Seyssens","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences, Department of Periodontology and Oral Implantology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0938-8887","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Christiaens","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences, Department of Periodontology and Oral Implantology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0647-6985","authenticated-orcid":false,"given":"Jeremy","family":"Pitman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences, Department of Periodontology and Oral Implantology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-2875","authenticated-orcid":false,"given":"Jan","family":"Cosyn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences, Department of Periodontology and Oral Implantology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13583"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.18\u20100338"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080435"},{"key":"e_1_2_11_5_1","first-page":"441","article-title":"Early implant placement following single\u2010tooth extraction in the esthetic zone: Biologic rationale and surgical procedures","volume":"28","author":"Buser D.","year":"2008","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g3.3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.11607\/ijp.8544"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2012.01921.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2017.10.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20102456(86)90046\u20102"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13120"},{"key":"e_1_2_11_12_1","first-page":"99","article-title":"A simplified socket classification and repair technique","volume":"19","author":"Elian N.","year":"2007","journal-title":"Practical Procedures & Aesthetic Dentistry"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13811"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2005.01193.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13276"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.03.017"},{"key":"e_1_2_11_17_1","first-page":"26","article-title":"Consensus statements and recommended clinical procedures regarding the placement of implants in extraction sockets","volume":"19","author":"H\u00e4mmerle C. 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