{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:48:25Z","timestamp":1775036905137,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030982","name":"Straumann Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To histometrically compare the osseointegration and crestal bone healing of a novel tapered, self\u2010cutting tissue\u2010level test implant with a standard tissue\u2010level control implant in a submerged healing regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In a mandibular minipig model, implants were inserted and evaluated histometrically after a healing period of 3, 6, and 12\u2009weeks. The primary outcome was the evaluation of bone\u2010to\u2010implant contact (BIC) and secondary outcomes were primary stability as per insertion torque and first BIC (fBIC). Outcomes for the test and control implants were compared using Wilcoxon signed\u2010rank tests and mixed linear regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Insertion torque values were significantly higher for the test (50.0\u2009\u00b1\u200926.4\u2009Ncm) compared to the control implants (35.2\u2009\u00b1\u200919.7 Ncm, <jats:italic>p<\/jats:italic>\u2009=\u2009.0071). BIC values of test implants were non\u2010inferior to those of control implants over the investigated study period. After 12\u2009weeks, the corresponding values measured were 81.62\u2009\u00b1\u200911.12% and 90.41\u2009\u00b1\u20094.81% (<jats:italic>p<\/jats:italic>\u2009=\u2009.1763) for test and control implants, respectively. Similarly, no statistical difference was found for fBIC values, except for the 12\u2009weeks outcome that showed statistically lower values for the test (\u2212675.58\u2009\u00b1\u2009590.88\u2009\u03bcm) compared to control implants (\u2212182.75\u2009\u00b1\u2009197.40\u2009\u03bcm, <jats:italic>p\u2009=<\/jats:italic>\u2009.0068).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Novel self\u2010cutting tissue\u2010level implants demonstrated noninferior osseointegration and crestal bone height maintenance to the tissue\u2010level implants. Histometric outcomes between both implants demonstrated test implants were statistically noninferior to control implants, despite substantial differences in the bone engagement mechanism and resulting differences in insertion torque and qualitative bone healing patterns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14318","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T07:59:27Z","timestamp":1721462367000},"page":"1299-1309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative osseointegration of hydrophobic tissue\u2010level tapered implants\u2014A preclinical in\u00a0vivo study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-5249","authenticated-orcid":false,"given":"Jean\u2010Claude","family":"Imber","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azita","family":"Khandanpour","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-0860","authenticated-orcid":false,"given":"Andrea","family":"Roccuzzo","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delia R.","family":"Irani","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2132-6363","authenticated-orcid":false,"given":"Dieter D.","family":"Bosshardt","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-5477","authenticated-orcid":false,"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-5555","authenticated-orcid":false,"given":"Benjamin E.","family":"Pippenger","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"},{"name":"Department of Preclinical Research Institut Straumann AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2006.00016.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12337"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2010.02117.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.140101.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00693.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300704"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.08.006"},{"key":"e_1_2_12_9_1","first-page":"12","article-title":"Immediate or early placement of implants following tooth extraction: Review of biological basis, clinical proceedures, and outcomes","volume":"19","author":"Chen S.","year":"2004","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2000.011S1033.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00153.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1765-8"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17186920"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.4594"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12419"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-03912-w"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-021-00367-2"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-03970-0"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13910"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02513.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.090728"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.10.1372"},{"key":"e_1_2_12_23_1","first-page":"1","article-title":"Relationship between implant geometry and primary stability in different bony defects and variant bone densities: An in\u00a0vitro study","volume":"13","author":"Ibrahim A.","year":"2020","journal-title":"Materials (Basel, Switzerland)"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02345-5"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12532"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1556\/imas.5.2013.4.3"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2014.03.017"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12212"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2011.00351.x"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000350"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12659"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2018.11.004"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/08941939.2013.817628"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000476"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1563\/1548-1336(1999)025<0185:ABQISF>2.3.CO;2"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01356.x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264475"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2023.101523"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13734"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13716"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2012.00464.x"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02170.x"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12600"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5732"},{"key":"e_1_2_12_45_1","first-page":"348","article-title":"The T\u00fcbingen immediate implant in clinical studies","volume":"33","author":"Schulte W.","year":"1978","journal-title":"Deutsch Zahn\u00e4rztl Zeitschr"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.11138\/orl\/2017.10.2.129"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12499"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516628868"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000438"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.14318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T07:59:56Z","timestamp":1729324796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.14318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,20]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/clr.14318"],"URL":"https:\/\/doi.org\/10.1111\/clr.14318","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,20]]},"assertion":[{"value":"2023-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}