{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:18:27Z","timestamp":1776986307560,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To histomorphometrically determine the effects of hard\u2010 and\/or soft\u2010tissue augmentation by applying the early implant placement protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The distal roots of the maxillary second and third premolars were extracted in 10 mongrel dogs. After 1 month, early implant placement was performed in the distal roots, resulting in buccal dehiscence defects. Four treatments were then randomly applied: (1) guided bone regeneration (GBR), (2) connective tissue grafting (CTG), (3) simultaneous GBR and CTG (GBR\u2009+\u2009CTG) and (4) no further treatment (control). Healing abutments were connected to all implants to allow non\u2010submerged healing. At 4 and 16\u2009weeks, tissue sections were harvested and histomorphometric analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Group GBR presented the largest total tissue thickness at 4\u2009weeks, but underwent a greater remodelling compared with the other groups between 4 and 16\u2009weeks. At 16\u2009weeks, the overall tissue thickness was largest in group GBR\u2009+\u2009CTG. This group was also the most favourable in terms of the level of the margo mucosae and the presence of mineralized tissue at the coronal level. Group CTG demonstrated a stable tissue thickness over time, with a larger thickness at 16\u2009weeks compared with group GBR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Simultaneous CTG and GBR resulted in the most\u2010favourable tissue thickness when applying the early implant placement protocol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14320","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T04:07:22Z","timestamp":1719029242000},"page":"1324-1334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of hard\u2010 and\/or soft\u2010tissue grafting with early implant placement: Histomorphometric outcomes of an exploratory study in canines"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7695-1708","authenticated-orcid":false,"given":"Hyun\u2010Chang","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Periodontology, Periodontal\u2010Implant Clinical Research Institute Kyung Hee University College of Dentistry, Kyung Hee University Medical Center  Seoul Korea"},{"name":"Clinic for Reconstructive Dentistry University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Periodontal\u2010Implant Clinical Research Institute Kyung Hee University College of Dentistry, Kyung Hee University Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-1320","authenticated-orcid":false,"given":"Ronald 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