{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T22:03:45Z","timestamp":1768773825902,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to explore the effect of depression and selective serotonin reuptake inhibitors on implant osseointegration and bone healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010eight 6\u2010 to 8\u2010week\u2010old SPF Sprague\u2013Dawley male rats were randomly divided into four groups: the Control group, the Fluoxetine group, the Depression group and the De&amp;Flu group. The rats in the Depression group and the De&amp;Flu group were subjected to a depression modelling process, and the rats in the Control group and the Fluoxetine group were raised normally. Then, a titanium implant was placed in the right tibia of each rat. In the Fluoxetine group and De&amp;Flu group, fluoxetine was injected subcutaneously daily, while subcutaneously injecting physiological saline in the Control group and Depression group. Collecting serum from the rats used for ELISA. The surgical area was cut for microcomputed tomography and histology observation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 12\u2009weeks, bone mineral density was lower in the De&amp;Flu group than in the Control group, Depression group and Fluoxetine group. Bone mineral density was also lower in the Depression group and the Fluoxetine group than in the Control group. The percentage of bone\u2013implant contact (BIC%) in De&amp;Flu rats was lower than in the Control, Depression and Fluoxetine groups. The BIC% in the Depression group and the Fluoxetine group was lower than in the Control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Depression and fluoxetine negatively affect bone density and implant osseointegration independently, and this damaging effect is exacerbated when both factors are present. The mechanism may be related to the dysregulation of the hypothalamic\u2013pituitary\u2013adrenal axis and inflammation in the body.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14323","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T11:40:29Z","timestamp":1720093229000},"page":"1355-1366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of depression and the antidepressant fluoxetine on osseointegration\u2014A pre\u2010clinical in\u00a0vivo experimental study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0358-0235","authenticated-orcid":false,"given":"Yundeng","family":"Xiaowen","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Hospital of Stomatology Hebei Medical University, Hebei Key Laboratory of Stomatology, Hebei Clinical Medical Research Centre for Oral Diseases  Shijiazhuang 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