{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:21:47Z","timestamp":1793305307321,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["APB\u2010MET\u201016\u2010070"],"award-info":[{"award-number":["APB\u2010MET\u201016\u2010070"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the systemic effect of non\u2010surgical peri\u2010implantitis treatment (NSPIT) with or without the administration of systemic metronidazole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this secondary analysis from a previously published clinical trial (NCT03564301), peri\u2010implantitis patients were randomized into two groups: test, receiving NSPIT plus 500\u2009mg of oral systemic metronidazole three times a day for 7\u2009days (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910); and control group, receiving NSPIT plus placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911). Serum samples were obtained at baseline, 3 and 6\u2009months after therapy to determine levels of inflammatory biomarkers, lipid fractions and complete blood counts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both treatment modalities produced improvements in clinical and radiographic parameters. After 6\u2009months from NSPIT, a substantial reduction in C\u2010reactive protein (6.9\u2009mg\/dL; 95% CI: 3.7 to 9.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and low\u2010density lipoprotein cholesterol (21.8\u2009mg\/dL; 95% CI: \u22126.9 to 50.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.013) as well as a modest increase in neutrophils counts (0.4\u2009\u00d7\u200910\n                      <jats:sup>3<\/jats:sup>\n                      \/\u03bcL; 95% CI: \u22120.4 to 1.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.010) was observed in the control group while the test group showed a significant reduction of TNF\u2010\u03b1 (110.1; 95% CI: 38.9 to 181.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NSPIT showed a short\u2010term beneficial systemic effect regardless of adjunctive use of systemic metronidazole.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.14339","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T10:59:26Z","timestamp":1722596366000},"page":"1519-1530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The systemic impact of non\u2010surgical treatment of peri\u2010implantitis with or without adjunctive systemic metronidazole: Secondary analysis of a randomized clinical trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-5884","authenticated-orcid":false,"given":"Antonio","family":"Li\u00f1ares","sequence":"first","affiliation":[{"name":"Periodontology Unit, Faculty of Odontology University of Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-523X","authenticated-orcid":false,"given":"Jose","family":"Dopico","sequence":"additional","affiliation":[{"name":"Periodontology Unit, Faculty of Odontology University of Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlota","family":"Blanco","sequence":"additional","affiliation":[{"name":"Periodontology Unit, Faculty of Odontology University of Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-3116","authenticated-orcid":false,"given":"Alex","family":"Pico","sequence":"additional","affiliation":[{"name":"Periodontology Unit, Faculty of Odontology University of Santiago de Compostela  Santiago de Compostela 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