{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:21:01Z","timestamp":1790828461643,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To date, no studies have exploited micro\u2010CT in humans to evaluate bone morphology and structure after bone augmentation with CAD\/CAM\u2010customized titanium mesh, in mandible and maxilla. The aim of this study was to assess the composition and microstructure of bone biopsy through micro\u2010CT analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Bone augmentation at both maxillary and mandible sites was performed on 30 patients randomly treated with customized mesh, either alone (M\u2212) or covered with resorbable membrane (M+), in both cases filled 50:50 with autogenous bone and xenograft. After 6\u2009months, biopsies were taken and micro\u2010CT was performed on consecutive 1\u2010mm\u2010thick VOIs from coronal to apical side, measuring tissue volumes, trabecular thickness, spacing, and number.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In both groups, irrespective of membrane use, bone tissue (M\u2212: 29.76% vs. M+: 30.84%) and residual graft material (M\u2212: 14.87% vs. M+: 13.11%) values were similar. Differences were site\u2010related (maxillary vs. mandibular) with higher percentage of bone tissue and trabecular density of low\u2010mineralized bone and overall bone in the mandible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The composition and structure of bone tissue, as assessed by micro\u2010CT after alveolar ridge augmentation using CAD\/CAM\u2010customized titanium meshes, showed similar features regardless of whether a collagen membrane was applied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.14342","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T12:09:42Z","timestamp":1722946182000},"page":"1546-1559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A\n                    <scp>3D<\/scp>\n                    micro\u2010\n                    <scp>CT<\/scp>\n                    assessment of composition and structure of bone tissue after vertical and horizontal alveolar ridge augmentation using\n                    <scp>CAD<\/scp>\n                    \/\n                    <scp>CAM<\/scp>\n                    \u2010customized titanium mesh"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5155-2807","authenticated-orcid":false,"given":"Alessandro","family":"Cucchi","sequence":"first","affiliation":[{"name":"Private Practice  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2171-1851","authenticated-orcid":false,"given":"Gregorio","family":"Marchiori","sequence":"additional","affiliation":[{"name":"Surgical Sciences and Technologies IRCCS Istituto Ortopedico Rizzoli  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sartori","sequence":"additional","affiliation":[{"name":"Surgical Sciences and Technologies IRCCS Istituto Ortopedico Rizzoli  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Fini","sequence":"additional","affiliation":[{"name":"Scientific Direction IRCCS Istituto Ortopedico Rizzoli  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Fiorino","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry Federico II University of Naples  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Donati","sequence":"additional","affiliation":[{"name":"Private Practice  Lucca Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Corinaldesi","sequence":"additional","affiliation":[{"name":"Section of Oral Science, Department of Biomedical and Neuromotor Sciences (DIBINEM) University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Maglio","sequence":"additional","affiliation":[{"name":"Surgical Sciences and Technologies IRCCS Istituto Ortopedico Rizzoli  Bologna 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