{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:11:21Z","timestamp":1789495881014,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this non\u2010inferiority randomized clinical trial was to compare the surgical and healing complications, vertical bone gain, and volumetric bone changes after vertical ridge augmentation using two different approaches: customized Ti\u2010reinforced d\u2010PTFE mesh versus customized CAD\/CAM Ti\u2010mesh.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Fifty patients with vertical bone defects were randomly treated with Ti\u2010reinforced d\u2010PTFE mesh (control group) or CAD\/CAM Ti\u2010mesh (test group) and a mix of autogenous bone and deproteinized bovine bone matrix. Surgical and healing complication rates (SCR\u2010HCR), vertical bone gain (VBG), regenerated bone volume (RBV), and regeneration rates (RR and ERR) were recorded and analysed [significance level (\u03b1) of 0.05].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 50 patients, 48 underwent bone augmentation surgery. SCR were 4% and 12% in PTFE and Ti\u2010mesh, whereas HCR were 12.5% and 8.3%. VBG were 5.79\u2009\u00b1\u20091.71\u2009mm (range: 3.2\u20138.8\u2009mm) in the PTFE group and 5.18\u2009\u00b1\u20091.61\u2009mm (range: 3.1\u20138.0\u2009mm) in the Ti\u2010mesh group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.233), whereas RBV were 1.46\u2009\u00b1\u20090.48\u2009cc and 1.26\u2009\u00b1\u20090.55. RR was 99.5% and 87.0%, demonstrating a statistically significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.013). Finally, the values related to pseudo\u2010periosteum, bone density, and implant stability were similar in the two study groups. Osseointegration rates were 98.2% and 98.3%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study confirmed the non\u2010inferiority of customized CAD\/CAM titanium meshes with respect to reinforced PTFE meshes in terms of surgical and healing complications. Although PTFE meshes showed higher vertical bone gain and regeneration rates than Ti\u2010meshes, no significant differences were found.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.14350","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T02:31:54Z","timestamp":1724466714000},"page":"1616-1639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Complication, vertical bone gain, volumetric changes after vertical ridge augmentation using customized reinforced PTFE mesh or Ti\u2010mesh. A non\u2010inferiority randomized clinical trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5155-2807","authenticated-orcid":false,"given":"Alessandro","family":"Cucchi","sequence":"first","affiliation":[{"name":"Private Practice  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Bettini","sequence":"additional","affiliation":[{"name":"Implant Center for Edentulism and Jawbone Atrophies, Maxillofacial Surgery and Odontostomatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Biomedical, Surgical and Dental Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"Private Practice  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9575-749X","authenticated-orcid":false,"given":"Debora","family":"Franceschi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinic Medicine University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Fiorino","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Reproductive and Odontostomatological Sciences \u2018Federico II\u2019 University of Naples  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Corinaldesi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences (DIBINEM) University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13850"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13720"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070001"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"129","article-title":"A novel technique for digitalisation and customisation of reinforced polytetrafluoroethylene meshes: Preliminary results of a clinical trial","volume":"15","author":"Cucchi A.","year":"2022","journal-title":"The International Journal of Oral 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