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Currently, there is limited evidence for the prognosis of dental implant treatment in Sj\u00f6gren's syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim\/Hypothesis<\/jats:title><jats:p>We hypothesized comparable clinical outcomes of implant\u2010supported restorations in pSS\u2010patients and control subjects, and improvement in oral health\u2010related quality of life 5\u2009years after restoration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Patients with pSS and matched (age, gender, and tooth region) control group were recruited between June 2016 and March 2020. The clinical and radiological examination were performed, and patient\u2010reported oral health impact profile (OHIP\u201049) questionnaire was used 2\u2009months (baseline), 1, 3, and 5\u2009years after prosthetic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 23 patients with pSS and 24 matched control subjects (all women, mean age: 57.1\u2009years). The overall DMFT (decayed\u2010missed\u2010filled\u2010tooth) was significantly higher (<jats:italic>p<\/jats:italic>\u2009=\u20090.008), symptoms of dry mouth were more severe (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), and unstimulated and chewing\u2010stimulated saliva flow rates were significantly lower (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in pSS than in control group. All implants survived with no implant mobility. At implant sites, the plaque index and probing depths did not differ (<jats:italic>p<\/jats:italic>\u2009=\u20090.301 and 0.446, respectively), but the gingival index was significantly higher (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) in pSS than control group. The mean marginal bone loss, prosthetic complications, and clinician\u2010reported aesthetic outcomes were similar in both groups after 5\u2009years. The OHIP scores were significantly higher in the pSS than control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but reduced significantly in both groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Replacement of missing single teeth with dental implants was successful in patients with pSS 5\u2009years after restoration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14356","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T13:22:22Z","timestamp":1725542542000},"page":"51-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognosis of Single Implant\u2010Supported Prosthesis in Patients With Primary Sj\u00f6gren's Syndrome: A Five\u2010Year Prospective Clinical Study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8768-274X","authenticated-orcid":false,"given":"Mandana","family":"Hosseini","sequence":"first","affiliation":[{"name":"Research Section for Oral Health, Society and Technology\/Oral Rehabilitation, Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3519-4103","authenticated-orcid":false,"given":"Simon Storg\u00e5rd","family":"Jensen","sequence":"additional","affiliation":[{"name":"Research Section for Oral Biology and Immunopathology\/Oral Surgery, Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Oral and Maxillofacial Surgery Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1444-9362","authenticated-orcid":false,"given":"Klaus","family":"Gotfredsen","sequence":"additional","affiliation":[{"name":"Research Section for Oral Health, Society and Technology\/Oral Rehabilitation, Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8045-8435","authenticated-orcid":false,"given":"Emil","family":"Hyldahl","sequence":"additional","affiliation":[{"name":"Research Section for Oral Biology and Immunopathology\/Oral Surgery, Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-5803","authenticated-orcid":false,"given":"Anne Marie Lynge","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Research Section for Oral Biology and Immunopathology\/Oral Pathology and Medicine, Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12950"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.151167"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"11","article-title":"The Long\u2010Term Efficacy of Currently Used Dental Implants: A Review and Proposed Criteria of Success","volume":"1","author":"Albrektsson T.","year":"1986","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2016.1249538"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189507"},{"issue":"5","key":"e_1_2_10_7_1","first-page":"1007","article-title":"Microflora in Oral Ecosystems in Primary Sj\u00f6gren's Syndrome","volume":"28","author":"Almst\u00e5hl A.","year":"2001","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12591"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(94)90143-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"issue":"1","key":"e_1_2_10_11_1","first-page":"54","article-title":"Implant\u2010Supported Fixed Prosthesis Treatment of a Patient With Sj\u00f6gren's Syndrome: A Clinical Report","volume":"8","author":"Binon P. 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