{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:06:43Z","timestamp":1789106803158,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE027857"],"award-info":[{"award-number":["R01DE027857"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002050","name":"Delta Dental Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004368","name":"Colgate-Palmolive Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Peri\u2010implant mucositis, a dysbiosis\u2010driven inflammatory disease, is a precursor to peri\u2010implantitis, underscoring the need for early disease management. Therefore, we investigated the efficacy of glycine powder in resolving clinical inflammation and restoring host\u2010microbial homeostasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty subjects were randomized to receive either glycine powder air\u2010abrasive debridement or ultrasonic instrumentation. Clinical parameters (probe depth [PD], modified Sulcular Bleeding Index [mSBI], modified Plaque Index [mPlI]), biofilm and peri\u2010implant crevicular fluid were collected at baseline and at 1\u2010day, 1\u2010, 3\u2010, 6\u2010weeks and 3\u2010 and 6\u2010months post\u2010therapy. Microbial recolonization was examined using 16S rDNA sequencing and immune response was semi\u2010quantified using a bead\u2010based 17\u2010plex microarray.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6\u2010months, both groups demonstrated non\u2010significant reductions in mSBI when compared to baseline (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05, Wald test, mixed model for repeated measures). However, mSBI and PD decreased in the test group from week\u20101 to 3\u2010months, while control group decreased at 1\u2010 and 3\u2010weeks only. mSBI was lower in the test group when compared to controls from Week\u20101 to 3\u2010months, while PD differed between groups at 6\u2009weeks and 3\u2010months. Glycine group demonstrated significant microbial shifts after 24\u2010h, increases in species richness and health\u2010compatible species, and loss of pathobionts (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, Dunn test). Pro\u2010inflammatory cytokines decreased from 1\u2010 to 6\u2010weeks or 3\u2010months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, Wald test). Comparable results were obtained in the ultrasonic group at 3\u2010weeks and sustained over 6\u2010weeks post\u2010therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Glycine therapy leads to early and sustained change in host\u2010microbial interactions when compared to ultrasonics, however, the changes wrought by both therapies were sustained for a maximum of 3\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> identifier: NCT05810558<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14361","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T08:29:11Z","timestamp":1727512151000},"page":"82-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of Glycine Powder Air\u2010Abrasive Debridement on Peri\u2010Implant Mucositis: A Randomized Control Trial of Clinical, Microbial, and Immunological Changes"],"prefix":"10.1111","volume":"36","author":[{"given":"Brian","family":"Partido","sequence":"first","affiliation":[{"name":"Dental Programs, Healthcare and Human Services Division Seattle Central Health Education Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Saraswat","sequence":"additional","affiliation":[{"name":"James Cancer Institute and Solove Research Center The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5844-1341","authenticated-orcid":false,"given":"Purnima S.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma15144850"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12155"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17\u20100739"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"60","article-title":"Clinical Practice Guidelines for Recall and Maintenance of Patients With Tooth\u2010Borne and Implant\u2010Borne Dental Restorations","volume":"90","author":"Bidra A. 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