{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:59:40Z","timestamp":1783508380357,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030982","name":"Straumann Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This controlled preclinical study analyzed the effect of implant surface characteristics on osseointegration and crestal bone formation in a grafted dehiscence defect minipig model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A standardized 3\u2009mm\u2009\u00d7\u20093\u2009mm acute\u2010type buccal dehiscence minipig model grafted with deproteinized bovine bone mineral and covered with a porcine collagen membrane after 2 and 8\u2009weeks of healing was utilized. Crestal bone formation was analyzed histologically and histomorphometrically to compare three implant groups: (1) a novel, commercially available, gradient anodized (NGA) implant, to two custom\u2010made geometric replicas of implant \u201c1,\u201d (2) a superhydrophilic micro\u2010rough large\u2010grit sandblasted and acid\u2010etched surface, and (3) a relatively hydrophobic micro\u2010rough large\u2010grit sandblasted and acid\u2010etched surface.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 2 and 8\u2009weeks, there was no difference between the amount and height of newly formed bone (NBH, new bone height; BATA, bone area to total area) for any of the groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). First bone\u2010to\u2010implant contact (fBIC) and vertical bone creep (VBC) at 2 and 8\u2009weeks were significantly increased for Groups 2 and 3 compared to Group 1 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). At 8\u2009weeks, osseointegration in the dehiscence (dehiscence bone\u2010implant\u2010contact; dBIC) was significantly higher for Groups 2 and 3 compared to Group 1 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The amount of newly formed bone (BATA) and NBH was not influenced by surface type. However, moderately rough surfaces demonstrated significantly superior levels of osseointegration (dBIC) and coronal bone apposition (fBIC) in the dehiscence defect compared to the NGA surface at 2 and 8\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>For this type of study, clinical trial registration is not required. This study was conducted at the Biomedical Department of Lund University (Lund, Sweden) and approved by the local Ethics Committee of the University (M\u2010192\u201014)<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14369","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T13:23:31Z","timestamp":1728566611000},"page":"127-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Osseointegration of Anodized vs. Sandblasted Implant Surfaces in a Guided Bone Regeneration Acute Dehiscence\u2010Type Defect: An In\u00a0Vivo Experimental Mandibular Minipig Model"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5354-9847","authenticated-orcid":false,"given":"Shakeel","family":"Shahdad","sequence":"first","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry, Institute of Dentistry Queen Mary University of London  London 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