{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:44:55Z","timestamp":1791575095774,"version":"4.3.4"},"reference-count":86,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The present trial evaluated the first\u2010time application of autogenous demineralized dentin graft with injectable platelet\u2010rich fibrin (ADDG\u2009+\u2009i\u2010PRF) versus autogenous demineralized dentin graft (ADDG), in alveolar ridge preservation (ARP) in the maxillary aesthetic zone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010two maxillary (<jats:italic>n<\/jats:italic>\u2009=\u200922) non\u2010molar teeth indicated for extraction were randomized into two groups (<jats:italic>n<\/jats:italic>\u2009=\u200911\/group). Extracted teeth were prepared into ADDG, implanted into extraction sockets with or without i\u2010PRF amalgamation and covered by collagen sponge. Cone\u2010beam computed tomography scans at baseline and 6\u2009months were compared to assess ridge\u2010dimensional changes. Keratinized tissue width, patient satisfaction, pain score and chair time were recorded. In the course of dental implant placements at 6\u2009months, bone core biopsies of engrafted sites were obtained and analysed histomorphometrically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reduction in ridge width was 1.71\u2009\u00b1\u20091.08 and 1.8\u2009\u00b1\u20091.35\u2009mm, while reduction in ridge height was 1.11\u2009\u00b1\u20090.76 and 1.8\u2009\u00b1\u20090.96\u2009mm for ADDG\u2009+\u2009i\u2010PRF and ADDG, respectively (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Significant differences in keratinized tissue width reduction were notable between ADDG\u2009+\u2009i\u2010PRF and ADDG (0.12\u2009\u00b1\u20090.34 and 0.58\u2009\u00b1\u20090.34\u2009mm respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.008). Postoperative pain scores were significantly lower in ADDG\u2009+\u2009i\u2010PRF (<jats:italic>p<\/jats:italic>\u2009=\u20090.012). All patients in the two groups were satisfied with no differences in chair time (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). No differences in total percentage area of newly formed bone, soft tissue or graft particles were observed between the groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ADDG alone or in combination with i\u2010PRF yields similar results regarding ARP clinically, quality of the formed osseous tissues, as well as patients' satisfaction. Yet, the addition of i\u2010PRF to ADDG tends to preserve the keratinized tissue and lessen postoperative pain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14372","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T09:04:36Z","timestamp":1729501476000},"page":"166-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Does Injectable Platelet\u2010Rich Fibrin Combined With Autogenous Demineralized Dentine Enhance Alveolar Ridge Preservation? A Randomized Controlled Trial"],"prefix":"10.1111","volume":"36","author":[{"given":"Odai","family":"Amer","sequence":"first","affiliation":[{"name":"Oral Medicine and Periodontology Department, Faculty of Dentistry Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-9807","authenticated-orcid":false,"given":"Nesma","family":"Shemais","sequence":"additional","affiliation":[{"name":"Oral Medicine and Periodontology Department, Faculty of Dentistry Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-3609","authenticated-orcid":false,"given":"Karim","family":"Fawzy El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Oral Medicine and Periodontology Department, Faculty of Dentistry Cairo University  Cairo Egypt"},{"name":"Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine Christian Albrechts 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