{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:13:03Z","timestamp":1787062383638,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the effect of polydeoxyribonucleotide (PDRN) on endosinus bone regeneration in a rabbit sinus model at sequential healing time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Eighteen New Zealand white rabbits were used. Bilateral sinus floor elevation (SFE) was performed. Two groups were randomly assigned to each sinus: (1) test group, in which SFE was performed using collagenated bone substitute material soaked with PDRN (concentration 2.0\u2009mg\/mL, dose 0.5\u2009mL), and (2) control group, in which SFE was performed using collagenated bone substitute material only. The experimental animals were sacrificed at 2, 4, and 8\u2009weeks (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096 at each healing time point). Microcomputed tomography (micro\u2010CT), histologic, and histomorphometric analyses were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The micro\u2010CT analysis revealed statistically significant increases in the mineralized tissue volume between 4 and 8\u2009weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Histologically, no specific intergroup difference was found in the pattern of new bone formation. Histomorphometrically, the area of newly formed bone (NB) was larger in the test group than in the control group at all healing time points (1.4 vs. 1.2\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      at 2\u2009weeks, 3.4 vs. 1.9\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      at 4\u2009weeks, and 5.7 vs. 4.5\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      at 8\u2009weeks; median value), but the difference was statistically significant only at 4\u2009weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). NB in set regions of interest (ROI_C, ROI_W, and ROI_M) tended to be greater in the test group than in the control group without statistical significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PDRN appeared to enhance new bone formation at all healing time points, but the improvement was statistically significant only at 4\u2009weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.14378","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T02:29:54Z","timestamp":1732069794000},"page":"239-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Polydeoxyribonucleotide (\n                    <scp>PDRN<\/scp>\n                    ) on Endosinus Bone Regeneration Following Sinus Floor Elevation: An Experimental In\u00a0Vivo Pilot Study"],"prefix":"10.1111","volume":"36","author":[{"given":"Hyunwoo","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Dentistry, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Youn","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Kyung Hee University College of Dentistry, Periodontal\u2010Implant Clinical Research Institute Kyung Hee University Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Il","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Kyung Hee University College of Dentistry, Periodontal\u2010Implant Clinical Research Institute Kyung Hee University Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Hyuk","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Kyung Hee University College of Dentistry, Periodontal\u2010Implant Clinical Research Institute Kyung Hee University Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-7447","authenticated-orcid":false,"given":"Daniel S.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-1320","authenticated-orcid":false,"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7695-1708","authenticated-orcid":false,"given":"Hyun\u2010Chang","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Kyung Hee University College of Dentistry, Periodontal\u2010Implant Clinical Research Institute Kyung Hee University Medical Center  Seoul Republic of Korea"},{"name":"Clinic of Reconstructive Dentistry University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"613","article-title":"Grafting of the Maxillary Sinus Floor With Autogenous Marrow and Bone","volume":"38","author":"Boyne P. 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