{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:03:15Z","timestamp":1791252195756,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014654","name":"Dentsply Sirona","doi-asserted-by":"publisher","award":["IIS\u2010D\u20102012\u2010031"],"award-info":[{"award-number":["IIS\u2010D\u20102012\u2010031"]}],"id":[{"id":"10.13039\/501100014654","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This 5\u2010year multicenter randomized clinical trial assessed the non\u2010inferiority of maxillary implant\u2010supported fixed complete dentures (FCDs) with four (4\u2010I) compared to six implants (6\u2010I) in terms of radiographic marginal bone level (MBL) changes after 5\u2009years in function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Individuals were randomly assigned to the 4\u2010I or 6\u2010I groups. Follow\u2010ups occurred at 1, 3, and 5\u2009years. At each visit, FCDs were unscrewed, clinical parameters (plaque index, bleeding on probing, pocket depth, and keratinized mucosa width) were recorded using a periodontal probe, periapical radiographs were obtained, and maintenance care was performed. MBL changes, incidence of techincal, prosthetic, and biological complications, treatments costs, and satisfaction were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 47 patients rehabiliated with 233 implants, survival rates were 99.3% for 6\u2010I and 100% for 4\u2010I (one early failure; 6\u2010I group). No significant MBL differences were observed at 5\u2009years between and within the groups. Both groups showed a decrease in keratinized mucosa width and experienced prosthetic and biological complications, but no peri\u2010implantitis. The 4\u2010I exhibited a significantly higher incidence of technical complications (16.6% vs. 0%)\u00a0Cost analysis favored 4\u2010I for initial and total costs. Clinician and patient satisfaction varied, with 4\u2010I preferred aesthetically and 6\u2010I functionally, particularly in speaking ability at earlier follow\u2010ups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of FCDs supported by four implants is non\u2010inferior to six implants in terms of radiographic MBL changes after 5\u2009years in function. Both groups demonstrated comparable survival rates and incidence of biological and prosthetic complications. The 4\u2010I was associated with higher technical complications and reduced overall treatment cost.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/register.clinicaltrials.gov\/\">ClinicalTrials.gov identifier<\/jats:ext-link>: NCT02405169<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14383","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T03:49:32Z","timestamp":1732506572000},"page":"298-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Fixed Full\u2010Arch Maxillary Prostheses Supported by Four Versus Six Implants: 5\u2010Year Results of a Multicenter Randomized Clinical Trial"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2893-3676","authenticated-orcid":false,"given":"Marco","family":"Toia","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology Malm\u00f6 University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano S.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora R.","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"},{"name":"Department of Dentistry State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Corr\u00e0","sequence":"additional","affiliation":[{"name":"Institute Franci  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3029-8130","authenticated-orcid":false,"given":"Andrea","family":"Ravid\u00e0","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0284-1108","authenticated-orcid":false,"given":"Denis","family":"Cecchinato","sequence":"additional","affiliation":[{"name":"Institute Franci  Padova 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