{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:09:00Z","timestamp":1788206940458,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["15\u2010013"],"award-info":[{"award-number":["15\u2010013"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the potential mid\u2010term benefit of the use of a bone substitute material in the reconstructive surgical treatment of peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 120 subjects (127 implants) affected by peri\u2010implantitis were followed over 3\u2009years in a multicenter randomized clinical trial. Participants had been randomized to either control (access flap surgery) or test group (access flap surgery and bone substitute material). Clinical, radiographic, and patient\u2010reported outcomes were assessed. The primary outcome was a composite measure including probing pocket depth \u2264\u20095\u2009mm, absence of bleeding and suppuration on probing, soft tissue recession \u2264\u20091\u2009mm, and implant neither reoperated nor lost. In an additional outcome (disease resolution), we allowed for one bleeding site and did not consider recession.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>While 14 implants (11%) were lost and a second surgical intervention had been performed at 3 implants (2.4%), pronounced improvements of clinical parameters were noted at remaining implants in both treatment groups at the 3\u2010year follow\u2010up. This was illustrated by a 3.2\u20133.5\u2009mm reduction in probing pocket depth and a marginal bone level gain of 1.1\u20131.3\u2009mm. The primary composite outcome, however, was only achieved at 14% of implants. The second composite outcome defining disease resolution was accomplished at 39% of implants. Patient\u2010reported outcomes were generally favorable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At 3\u2009years, the use of a bone substitute material in the surgical therapy of peri\u2010implantitis did not result in a clear benefit over access flap surgery alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/\">ClinicalTrials.gov<\/jats:ext-link> identifier: NCT0307706<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14393","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T11:05:57Z","timestamp":1734692757000},"page":"436-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Bone Substitute Material in the Surgical Therapy of Peri\u2010Implantitis\u20143\u2010Year Outcomes of a Randomized Controlled Trial"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2070-5194","authenticated-orcid":false,"given":"Lamija","family":"Alibegovic","sequence":"first","affiliation":[{"name":"Department of Periodontology, Institute of Odontology The Sahlgrenska Academy at University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5172-5165","authenticated-orcid":false,"given":"Anna","family":"Trullenque\u2010Eriksson","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Institute of Odontology The Sahlgrenska Academy at University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-5907","authenticated-orcid":false,"given":"Alberto","family":"Ortiz\u2010Vig\u00f3n","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Ortiz\u2010Vig\u00f3n, PerioCentrum  Bilbao 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