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This study aimed to assess the clinical outcomes of dental implants in patients carrying <jats:italic>WNT10A<\/jats:italic> mutations with different molecular statuses and phenotypes over a long\u2010term follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients with tooth agenesis were screened by whole\u2010exome sequencing (WES) from January 2010 to September 2023. Carriers of pathogenic <jats:italic>WNT10A<\/jats:italic> mutations who underwent subsequent dental implant therapy were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>WES identified 66 patients with tooth agenesis carrying <jats:italic>WNT10A<\/jats:italic> mutations. Of these, 27 patients (11 males\/16 females; mean age 19.6\u2009years) met the inclusion criteria. Homozygotes had significantly more missing teeth (24.4\u2009\u00b1\u20093.8) than heterozygotes (10.9\u2009\u00b1\u20095.1, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and compound heterozygotes (13.8\u2009\u00b1\u20093.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). A total of 160 conventional implants were placed. Seven implants were lost in four patients before final prosthesis placement, resulting in overall failure rates of 14.8% at the subject level and 4.4% at the implant level. The 5\u2010year cumulative survival rate (range: 0.23\u201312.74\u2009years) was 85.2% and 95.6% at the subject and implant levels, respectively. The mean marginal bone loss (MBL) was 0.80\u2009mm (95% CI: 0.59\u20131.02). Subgroup analysis revealed higher MBL in homozygotes (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), sites requiring extensive bone augmentation (<jats:italic>p<\/jats:italic>\u2009=\u20090.016), anterior regions (<jats:italic>p<\/jats:italic>\u2009=\u20090.031), and full\u2010arch bridge cases (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Patient satisfaction and OHIP\u2010C49 scores were favorable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Implant rehabilitation is predictable for patients with <jats:italic>WNT10A<\/jats:italic> mutations. However, increased MBL observed in homozygotes with severe tooth agenesis and in cases requiring extensive alveolar bone augmentation highlights the importance of genetic diagnosis prior to implant therapy in patients with severe tooth agenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14402","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T03:43:45Z","timestamp":1737171825000},"page":"505-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dental Implant Rehabilitation in Patients Carrying <i>WNT10A<\/i> Mutations With Different Molecular Statuses and Phenotypes: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6842-9378","authenticated-orcid":false,"given":"Jiaqi","family":"Dou","sequence":"first","affiliation":[{"name":"Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology  Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinggang","family":"Dai","sequence":"additional","affiliation":[{"name":"Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology  Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinbo","family":"Yu","sequence":"additional","affiliation":[{"name":"Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology  Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yining","family":"He","sequence":"additional","affiliation":[{"name":"Biostatistics Office of Clinical Research Unit, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Dai","sequence":"additional","affiliation":[{"name":"Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology  Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology  Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8352-6256","authenticated-orcid":false,"given":"Yiqun","family":"Wu","sequence":"additional","affiliation":[{"name":"Second Dental Center, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology  Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"49","article-title":"Which Hard Tissue Augmentation Techniques Are the Most Successful in Furnishing Bony Support for Implant Placement?","volume":"22","author":"Aghaloo T. 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