{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T04:07:47Z","timestamp":1748750867401,"version":"3.41.0"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify changes in immunological, microbiological, and histological biomarkers that may indicate resistance during the induction phase and resilience during the resolution phase of experimental peri\u2010implant mucositis (PiM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The search was performed in MEDLINE, EMBASE, Web of Science, SCOPUS, Cochrane Library, and LILACS databases. Prospective interventional studies assessing biomarkers during experimental PiM were included. The risk of bias was assessed using the Risk Of Bias In Non\u2010Randomized Studies of Interventions (ROBINS\u2010I) tool. Meta\u2010analyses were conducted using random\u2010effects models. The GRADE approach was used to determine the certainty of evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven out of 6008 studies were included. Clinical parameters (mPI and mGI) effectively characterized the experimental PiM model. Due to methodological variability and conflicting results, a definitive interpretation of microbiological and histological biomarkers was not possible. The meta\u2010analysis revealed that IL\u20101\u03b2 and the volume of peri\u2010implant crevicular fluid (PICF) indicated non\u2010resistance during the induction phase. In contrast, TNF\u2010\u03b1, IL\u20106, IL\u20108, IL\u201017, MMP\u20108, and IFN\u2010\u03b3 remained stable. Regarding the resolution phase, IL\u20101\u03b2 returned to baseline levels (SMD: 1.13; 95% CI: \u22120.81, 3.06), and the volume of PICF (MD: 0.08; 95% CI: 0.03, 0.13) remained significantly elevated compared to day 0. However, TNF\u2010\u03b1, IL\u20106, IL\u20108, IL\u201017, MMP\u20108, and IFN\u2010\u03b3 did not significantly differ from baseline levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Moderate to very low evidence suggested that the biomarkers IL\u20101\u03b2 and the volume of PICF indicated a lack of resistance while suggesting resilience and non\u2010resilience, respectively. The biomarkers TNF\u2010\u03b1, IL\u20106, IL\u20108, IL\u201017, MMP\u20108, and IFN\u2010\u03b3 demonstrated resistance and resilience.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14427","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T08:04:18Z","timestamp":1741853058000},"page":"525-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential Biomarkers Indicating Resistance or Resilience in Experimental Peri\u2010Implant Mucositis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6374-511X","authenticated-orcid":false,"given":"Aldrin Andr\u00e9","family":"Huam\u00e1n\u2010Mendoza","sequence":"first","affiliation":[{"name":"Division of Periodontics, Department of Stomatology, School of Dentistry University of S\u00e3o Paulo (USP)  S\u00e3o Paulo S\u00e3o Paulo 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