{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:36:17Z","timestamp":1773725777556,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"S30","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To identify patient\u2010reported outcomes (PROs) and clinician\u2010reported outcomes (ClinROs) and their outcome measures (PROMs and CROMs) used in prospective studies comparing immediate, early, and delayed implant loading protocols in edentulous maxilla patients receiving implant\u2010supported prostheses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Protocol\u2010driven electronic searches were conducted across MEDLINE, Embase, Scopus, Web of Science, Cochrane databases\u2014January 2014 to May 2024\u2014to identify prospective interventional and observational studies comparing immediate, early, delayed implant loading in maxillary edentulous patients. Zygomatic implants were excluded. Risk of bias was performed using Cochrane RoB 2 and ROBINS\u2010I, and results were reported descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five studies were included, of which four compared immediate versus delayed loading and one study compared immediate versus early loading. PROMs like visual analog scale (VAS) tool (reported in 80%) to evaluate 7 PROs: pain, overall satisfaction, comfort, speech, masticatory function, esthetics, and self\u2010esteem. Three studies reported Oral Health Impact Profile (OHIP\u201019, OHIP\u201020), McGill Pain Questionnaire, and condition\u2010specific instruments assessing two outcomes: chewing ability and muscular activity during oral functions. ClinROs varied considerably between studies, demonstrating significant methodological diversity. ClinROs included implant stability, accuracy, occlusal parameters, periodontal health metrics, surgical outcomes, and esthetic evaluation via VAS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PROs were predominantly assessed using VAS to evaluate patient satisfaction, pain, function, and esthetics, followed by the OHIP Questionnaire for quality\u2010of\u2010life assessment in immediate versus early\/delayed loading protocols. ClinROs showed no standardized approach, creating significant heterogeneity in the reported outcomes. Standardization of assessment methods and reporting of PROMs\/CROMs is needed to optimize analyzing patient\u2010centered outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.14451","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:22:24Z","timestamp":1772958144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patient\u2010 and Clinician\u2010Reported Outcomes and Outcome Measures Evaluating Timing of Implant Loading in the Edentulous Maxilla: A Systematic Review of Prospective Studies"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4181-3975","authenticated-orcid":false,"given":"Claudio Mendes","family":"Pannuti","sequence":"first","affiliation":[{"name":"Division of Periodontology, Department of Stomatology, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Department of Stomatology, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Periodontology and Oral Implantology, Dental Research Division Guarulhos University \u2013 UNG  Guarulhos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella Neme Ribeiro","family":"Reis","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Department of Stomatology, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5905-5079","authenticated-orcid":false,"given":"Cristina Cunha","family":"Villar","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Department of Stomatology, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Francisco","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry, Faculty of Dental Medicine Lisbon University  Lisbon Portugal"},{"name":"Implantology Institute  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5669-912X","authenticated-orcid":false,"given":"Giuseppe A.","family":"Romito","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Department of Stomatology, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678\u20107757\u20102018\u20100600"},{"issue":"5","key":"e_1_2_10_3_1","first-page":"446","article-title":"A Modified Short Version of the Oral Health Impact Profile for Assessing Health\u2010Related Quality of Life in Edentulous Adults","volume":"15","author":"Allen F.","year":"2002","journal-title":"International Journal of Prosthodontics"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2018.03.022"},{"key":"e_1_2_10_5_1","first-page":"1","article-title":"Osseointegrated Implants in the Treatment of the Edentulous Jaw. 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