{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:30:24Z","timestamp":1791243024829,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report the 7\u2010year outcomes of a randomized clinical trial evaluating a reconstructive surgical procedure of peri\u2010implantitis with a bone substitute in combination with either concentrated growth factor (CGF) or collagen membrane (CM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The original population consisted of 57 patients with at least one implant diagnosed with peri\u2010implantitis exhibiting two\u2010, three\u2010, or four\u2010wall intrabony defects \u2265\u20093\u2009mm which were filled with a xenogenic bone grafting material and covered with either CGF or CM. Clinical and radiographic parameters, treatment success, and disease recurrence frequencies were evaluated over the 7\u2010year follow\u2010up period of supportive periodontal\/peri\u2010implant care. Relationships between prognostic indicators\/predictors and treatment success and failure were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen patients (24 implants) (CGF group) and 18 (25 implants) (CM group) completed the 7\u2010year follow\u2010up. Although short\u2010term improvements in clinical and radiographic outcomes were observed, a tendency toward relapse was detected through time. At implant level, CM group demonstrated significantly more favorable outcomes for deepest PPD and radiographic vertical defect depth (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043) compared to CGF group. At 7\u2009years, treatment success was achieved in 23.1% of CGF and 30.8% of CM patients, while disease recurrence occurred in 34.6% and 30.8%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The presence of baseline suppuration was the only significant patient\u2010level predictor for treatment failure (OR\u2009=\u200915.45; 95% CI: 1.42\u2013168.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both protocols led to comparable clinical and radiographic outcomes. Long\u2010term treatment success was limited, with increasing failure rates over time. Baseline suppuration had a significant negative impact on treatment outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.14466","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T08:49:28Z","timestamp":1750409368000},"page":"1202-1218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Long\u2010Term Treatment Outcomes of Peri\u2010Implantitis Reconstructive Therapy: 7\u2010Year Survival and Success of a Randomized Clinical Trial"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-9658","authenticated-orcid":false,"given":"Sila Cagri","family":"Isler","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Gazi University  Ankara Turkey"},{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern 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