{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T19:51:38Z","timestamp":1793994698308,"version":"4.8.0"},"reference-count":90,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study assessed 12\u2010month post\u2010loading 3D peri\u2010implant radiographic bone changes in osteoporotic women receiving a single titanium\u2010zirconium bone\u2010level tapered dental implant with a hydrophilic surface.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a prospective case series involving 18 post\u2010menopausal osteoporotic women in need of a single dental implant. A standardized CBCT scan was performed after implant placement and at 12\u2009months post\u2010loading to assess peri\u2010implant bone changes. The Implant Stability Quotient (ISQ) was recorded after implant placement, at implant impression, loading, and 12\u2009months post\u2010loading. Peri\u2010implant clinical parameters were recorded at 6 and 12\u2009months post\u2010loading and during the last visit implant survival and success were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen patients completed all study visits, and implant placement was uneventful for all participants. A statistically significant difference (reduction) from implant placement to 12\u2009months post\u2010loading was observed in terms of radiographic buccal bone width and palatal\/lingual width (\u0394Bw\u20100: 0.53\u2009mm, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and \u0394Pw\u20100: 0.47\u2009mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.006), as well as in terms of vertical distance between the implant shoulder and the first bone to implant contact on the buccal and palatal\/lingual aspect (\u0394BICb: \u22120.26\u2009mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.005 and \u0394BICp: \u22120.46\u2009mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.018). ISQ increased during osseointegration, and a high implant survival (100%) and success rate (from 81.3% to 100% based on 3 different sets of criteria) were recorded at 12\u2009months post\u2010loading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this case series, osteoporotic patients treated with single titanium\u2010zirconium implants showed high survival rates, predictable\u00a012\u2010month implant outcomes, and physiologic peri\u2010implant bone remodelling.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> NCT02884401<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.14469","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T04:59:03Z","timestamp":1751950743000},"page":"1234-1247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Radiographic Peri\u2010Implant Bone Changes in Osteoporotic Women Treated With a Ti\u2010Zr, Bone Level Tapered Implant With a Hydrophilic Surface: A 12\u2010Month Prospective Case\u2010Series"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-1997","authenticated-orcid":false,"given":"Calciolari","family":"Elena","sequence":"first","affiliation":[{"name":"Centre for Oral Clinical Research, Institute of Dentistry, Faculty of Medicine and Dentistry Queen Mary University of London  London UK"},{"name":"Department of Medicine and Surgery University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6841-458X","authenticated-orcid":false,"given":"Mardas","family":"Nikos","sequence":"additional","affiliation":[{"name":"Centre for Oral Clinical Research, Institute of Dentistry, Faculty of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palaska","family":"Iro","sequence":"additional","affiliation":[{"name":"Centre for Oral Clinical Research, Institute of Dentistry, Faculty of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tagliaferri","family":"Sara","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-9073","authenticated-orcid":false,"given":"Donos","family":"Nikolaos","sequence":"additional","affiliation":[{"name":"Centre for Oral Clinical Research, Institute of Dentistry, Faculty of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"11","article-title":"The Long\u2010Term Efficacy of Currently Used Dental Implants: A Review and Proposed Criteria of Success","volume":"1","author":"Albrektsson T.","year":"1986","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14135"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.01.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0355"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0295-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600108"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00148.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01473.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300704"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080360"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1990.010105.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12531"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514554949"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12597"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12550"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12950"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12498"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12936"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02296.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2010.02.014"},{"key":"e_1_2_11_22_1","unstructured":"Commission E.2012.\u201cRadiation Protection: Cone Beam CT for Dental and Maxillofacial Radiology. Evidence Based Guidelines. A Report Prepared by the Sedentexct Project.\u201d"},{"key":"e_1_2_11_23_1","first-page":"137","article-title":"Is Osteoporosis a Risk Factor for Osseointegration of Dental Implants?","volume":"8","author":"Dao T. T.","year":"1993","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.05.021"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02561.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2003.tb00210.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12566"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12518"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12077"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02113.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02105.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.dmfr.4600729"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.06.035"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02031.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-008-0870-4"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2009.00518.x"},{"key":"e_1_2_11_37_1","first-page":"460","article-title":"Correlation Between Bone Mineral Density of Jaws and Skeletal Sites in an Iranian Population Using Dual x\u2010Ray Energy Absorptiometry","volume":"10","author":"Esfahanizadeh N.","year":"2013","journal-title":"Dental Research Journal (Isfahan)"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30678"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2001.tb00128.x"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70191-5"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01626.x"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/20522657"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01909.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02050.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(93)90240-O"},{"key":"e_1_2_11_46_1","first-page":"905","article-title":"Effect of Osteoporotic Status on the Survival of Titanium Dental Implants","volume":"23","author":"Holahan C. M.","year":"2008","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00206.x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-69-827-1019"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12468"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.116494"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14144"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02369.x"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls163"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1179\/crn.2013.022"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014509"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2003.01810.x"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.03.050"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31823dbbf7"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02094.x"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-009-0023-2"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.12.004"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00204.x"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12231"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-010-0014-3"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01207.x"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511431252"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13143"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100501.2003.140508.x"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12367"},{"key":"e_1_2_11_70_1","first-page":"65","article-title":"A Prospective Study of 3\u2009Weeks' Loading of Chemically Modified Titanium Implants in the Maxillary Molar Region: 1\u2010Year Results","volume":"24","author":"Roccuzzo M.","year":"2009","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00906.x"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30518"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02821-8"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01014.x"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0278\u20102391(97)90173\u20107"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13596"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/19424396.2008.12224242"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-19-00351"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2011.00610.x"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12827"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1089\/152460901753285732"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2015.02.015"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-1955-8"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.4.546"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12766"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90218-E"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-849X.2008.00433.x"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.84303"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012001019.x"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.03.662"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.10.011"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.14469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T06:20:51Z","timestamp":1759472451000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.14469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":90,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/clr.14469"],"URL":"https:\/\/doi.org\/10.1111\/clr.14469","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,8]]},"assertion":[{"value":"2024-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}