{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:06:13Z","timestamp":1787166373225,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030982","name":"Straumann Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The effect of osteotomy overpreparation, and thus lack of primary stability, on implant osseointegration and crestal bone volume maintenance was investigated by comparing placement of dental implants with either a standard osteotomy preparation (NP) or an overprepared osteotomy (OP) where the final osteotomy drill was larger in diameter than the implant placed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Bone\u2010level implants (\u00d83.3\u2009mm diameter) were placed in the mandible of minipigs with two preparation techniques: an NP (Group 1) and an OP to a final osteotomy of 3.5\u2009mm in diameter (Group 2) and submerged for 2 and 8\u2009weeks. An Implant Stability Quotient (ISQ) was measured for each implant at placement. Implant survival, defined histologically as the absence of fibrous encapsulation and the presence of direct bone\u2010to\u2010implant contact, osseointegration and crestal bone formation were analysed histologically and histomorphometrically to compare the preparation techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A 100% survival for both preparation types was observed. The mean ISQ at insertion for Groups 1 and 2 was 69.35\u2009a.u. (95% CI: 68.02\u201370.68) and 11.95\u2009a.u. (95% CI: 10.53\u201313.37) respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). At 2 and 8\u2009weeks, there was no difference between the two groups for total bone\u2010to\u2010implant contact (tBIC) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Group 2 demonstrated significantly higher mean first bone\u2010to\u2010implant contact (fBIC), coronal bone\u2010to\u2010implant contact (cBIC) and bone\u2010area\u2010to\u2010total\u2010area (BATA) at 2 and 8\u2009weeks compared to Group 1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Implants inserted into an overprepared osteotomy with no primary stability successfully osseointegrated. At 2 and 8\u2009weeks, OP resulted in significantly more coronal bone apposition and maintenance of coronal bone volume as measured by fBIC, cBIC and BATA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70006","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T09:41:08Z","timestamp":1753263668000},"page":"1346-1359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Osseointegration in the Absence of Primary Stability: An Experimental Preclinical Mandibular Minipig Overpreparation In\u00a0Vivo Model"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1234-521X","authenticated-orcid":false,"given":"Thomas","family":"Gill","sequence":"first","affiliation":[{"name":"Institute of Dentistry, Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"},{"name":"Department of Restorative Dentistry, the Royal London Dental Hospital Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansley","family":"Ooi","sequence":"additional","affiliation":[{"name":"Institute of Dentistry, Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"},{"name":"Private Practice  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Tezulas","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Faculty of Dental Surgery University of Malta  Msida Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviva","family":"Petrie","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Eastman Dental Institute University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Rawlinson","sequence":"additional","affiliation":[{"name":"Institute of Dentistry, Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2135-6503","authenticated-orcid":false,"given":"Mario","family":"Roccuzzo","sequence":"additional","affiliation":[{"name":"Private Practice  Torino Italy"},{"name":"Department of Maxillo\u2010Facial Surgery University of Torino  Torino Italy"},{"name":"Department of Periodontics and Oral Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakeel","family":"Shahdad","sequence":"additional","affiliation":[{"name":"Institute of Dentistry, Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"},{"name":"Department of Restorative Dentistry, the Royal London Dental Hospital Barts Health NHS Trust  London 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