{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:11:34Z","timestamp":1791807094700,"version":"4.3.4"},"reference-count":96,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to develop a novel self\u2010glazed zirconia (SZr) dental implant featuring micro\/nano\u2010roughened thread and polished neck, and to examine its properties both in\u00a0vitro and in\u00a0vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      The micro\/nano\u2010roughened SZr surfaces (SZr\u2010MN) were manufactured using sandblasting and chemical vapor deposition. Surface topography, elemental composition, roughness, and contact angle were systematically characterized.\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Streptococcus mutans<\/jats:italic>\n                      <\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      were used to evaluate bacterial adhesion. Bone marrow mesenchymal stem cells (BMSCs) and human immortalized keratinocytes were used to assess cell adhesion, proliferation, and osteogenic differentiation. The sandblasting large\u2010grit acid\u2010etching treated titanium (Ti) surfaces (Ti\u2010SLA) served as the control. Ti and SZr implants were inserted into the mandibles of Beagle dogs, followed by radiological, fluorescent, and histomorphometric analyses after 8 and 12\u2009weeks of healing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The SZr\u2010MN surface exhibited micro\u2010scale ravines and gullies densely covered with curled, sheet\u2010like nano\u2010structures, which led to suitable roughness and improved hydrophilicity. Compared to the Ti\u2010SLA surface, the SZr\u2010MN surface demonstrated significantly reduced bacterial adhesion, along with increased adhesion and osteogenic differentiation of BMSCs. Consequently, the SZr implant achieved more extensive and denser surrounding bone tissue and enhanced osseointegration compared to the Ti implant, while both showed comparable dimensions of peri\u2010implant soft and hard tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The novel SZr implant surfaces demonstrated excellent antibacterial activity, biocompatibility, and proosteogenic effect, leading to enhanced osseointegration and satisfactory soft tissue sealing. Our findings offer a unique perspective on improving the biological activity of zirconia dental implants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70021","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T06:50:32Z","timestamp":1756104632000},"page":"1458-1473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Novel Micro\/Nano\u2010Roughened Self\u2010Glazed Zirconia Implant With Enhanced Osseointegration and Satisfactory Soft Tissue Sealing: An In\u00a0Vitro and In\u00a0Vivo Study"],"prefix":"10.1111","volume":"36","author":[{"given":"Minghao","family":"Zuo","sequence":"first","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University  Hangzhou 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