{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:11:54Z","timestamp":1777975914152,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004584","name":"Conseil R\u00e9gional de Bretagne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the effect of M101 gel in bone and peri\u2010implantitis healing and its safety of use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>M101 gel and solution (1\u2009g\/L) were evaluated in four different models: (i) human osteoblast culture; (ii) mouse calvarial defect; (iii) extraction model in dogs; (iv) peri\u2010implantitis model in dogs. M101 cytocompatibility was evaluated in osteoblasts, and expression of ALP, Runx2, and BMP\u20102 was determined. Calvarial defect was induced in mice by bone drilling, and healing was evaluated after 5\u2009weeks. In dogs, peri\u2010implantitis was treated by non\u2010surgical and surgical approaches with or without M101 gel application. Analyses were performed after 2\u2009months. Socket healing was evaluated by micro\u2010CT after tooth extraction. Local and systemic responses were evaluated after gel administration and intravenous injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cytocompatibility of M101 was confirmed in osteoblasts, and ALP, Runx2, and BMP\u20102 gene expression was increased after exposure (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In mice, calvarial bone defect healing was 1.6 folds more in the M101 gel treated group than in the untreated group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the extraction model, the local M101 gel application and systemic M101 administration did not induce an immunological response. In the peri\u2010implantitis dog model, M101 gel as an adjuvant to non\u2010surgical treatment led to improved PiPD reduction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) when compared to non\u2010surgical treatment without M101 gel. No difference was observed when used as an adjunct to surgical treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>M101 may be a safe and interesting candidate as an adjuvant to improve bone healing and non\u2010surgical treatment in peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70022","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T04:17:21Z","timestamp":1755749841000},"page":"1474-1485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of a Gel Loaded With\n                    <scp>M101<\/scp>\n                    on Bone and Peri\u2010Implantitis Healing: An Experimental In\u00a0Vivo Study"],"prefix":"10.1111","volume":"36","author":[{"given":"C\u00e9line","family":"Stutz","sequence":"first","affiliation":[{"name":"INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS)  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Petit","sequence":"additional","affiliation":[{"name":"INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS)  Strasbourg France"},{"name":"Facult\u00e9 de Chirurgie\u2010Dentaire Universit\u00e9 de Strasbourg  Strasbourg France"},{"name":"P\u00f4le de M\u00e9decine et Chirurgie Bucco\u2010Dentaires H\u00f4pitaux Universitaires de Strasbourg  Strasbourg 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Facultade de Veterinaria, Terra Campus Universidade de Santiago de Compostela  Lugo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"L\u00f3pez\u2010Pe\u00f1a","sequence":"additional","affiliation":[{"name":"iBoneLab SL  Lugo Spain"},{"name":"Department of Veterinary Clinical Sciences, Facultade de Veterinaria, Terra Campus Universidade de Santiago de Compostela  Lugo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4130-1526","authenticated-orcid":false,"given":"Fernando","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"iBoneLab SL  Lugo Spain"},{"name":"Department of Veterinary Clinical Sciences, Facultade de Veterinaria, Terra Campus Universidade de Santiago de Compostela  Lugo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Garc\u00eda","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Veterinary 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