{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:47:26Z","timestamp":1789721246225,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["779322"],"award-info":[{"award-number":["779322"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the efficacy and safety of a cell\u2010based therapy for 3D bone augmentation of severe alveolar bone defects prior to dental implant placement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A Phase 2 randomized controlled clinical trial evaluated the safety and efficacy of a cell therapy using expanded autologous iliac crest\u2010derived mesenchymal cells seeded on a synthetic bioabsorbable bone substitute covered with a non\u2010resorbable membrane. The control group received an autogenous bone block graft. After 5\u2009months, CBCT scans were compared to measure the bone volume changes achieved after the regenerative surgery. Subsequently, dental implants were placed in the regenerated areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 48 patients were included and randomized (36 patients in the test group and 12 in the control group). However, seven patients did not reach the minimum required number of expanded MSCs and were therefore unable to be treated. The tested intervention demonstrated significantly greater gains in bone volume, with a mean difference of 480.01\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032). Similarly, the mean change in bone crest volume from baseline to 5\u2009months was notably higher in the test group (1066.91\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      ) compared to the control group (586.9\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      ). Adverse reactions and patient morbidity were minor in both groups. Implants were placed on the regenerated bone, and all were integrated successfully in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The cell\u2010based therapy resulted in significant changes in bone volume compared to the control treatment, enabling dental implants in all patients. The procedure was associated with minimal adverse effects and patient morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT03373052, NCT04297813\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70025","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T13:04:43Z","timestamp":1755867883000},"page":"1498-1514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bone Augmentation of Atrophic Alveolar Ridges Using a Synthetic Bone Substitute With Mesenchymal Stem Cells: A Randomized, Controlled Clinical Trial"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-5755","authenticated-orcid":false,"given":"Mariano","family":"Sanz","sequence":"first","affiliation":[{"name":"Etiology and Therapy of Periodontal and Periimplant Diseases (ETEP) Research Group, Faculty of Odontology Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7581-6413","authenticated-orcid":false,"given":"Cecilie","family":"Gjerde","sequence":"additional","affiliation":[{"name":"Center of Translational Oral Research \u2010 Tissue Engineering, Department of Clinical Dentistry, Faculty of Medicine University of Bergen (UiB)  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-9704","authenticated-orcid":false,"given":"Bj\u00f8rn Tore","family":"Gjertsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Faculty of Medicine University of Bergen (UiB)  Bergen Norway"},{"name":"Department of Clinical Science, Hematology Section Haukeland University Hospital (HUH)  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-5907","authenticated-orcid":false,"given":"Alberto","family":"Ortiz\u2010Vig\u00f3n","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal and Periimplant Diseases (ETEP) Research Group, Faculty of Odontology Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1681-428X","authenticated-orcid":false,"given":"Nerea","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal and Periimplant Diseases (ETEP) Research Group, Faculty of Odontology Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8779-512X","authenticated-orcid":false,"given":"Alain","family":"Hoornaert","sequence":"additional","affiliation":[{"name":"CHU Nantes, UIC 11 Odontologie Universit\u00e9 de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4684-4770","authenticated-orcid":false,"given":"Jordi","family":"Caballe\u2010Serrano","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Universitat Internacional de Catalunya (UIC)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3329-4845","authenticated-orcid":false,"given":"Maria","family":"Giralt\u2010Hernando","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Universitat Internacional de Catalunya (UIC) 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