{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T04:39:46Z","timestamp":1764650386599,"version":"3.46.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/08067\u20103","2021\/08538\u20106"],"award-info":[{"award-number":["2021\/08067\u20103","2021\/08538\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.899928\/2023\u201000","41\/2017"],"award-info":[{"award-number":["88887.899928\/2023\u201000","41\/2017"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Odanacatib (ODN), a cathepsin K inhibitor, is a drug that reduces bone resorption while preserving bone formation. ODN was initially developed for the treatment of postmenopausal osteoporosis, but further development as a systemic medication has been discontinued. Here, we propose ODN as a topical treatment, the coating of dental implants, to achieve an anabolic shift of early osseointegration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>To this aim, we have coated double acid etching titanium implants (SLA) with and without ODN dispersed in a simulated body fluid (SBF). The implants were inserted into the tibia of 72 male Wistar rats and osseointegration was studied on Days 15 and 40. Biomechanical testing, micro\u2010computed microtomography, and histomorphometric analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Biomechanical testing reveals that after 15\u2009days of healing, removal torque increased from 2.5 Ncm (1.5\u20134.4) to 3.9 Ncm (1.7\u20137.6) when comparing SBF alone with SBF containing ODN, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). Consistently, micro\u2010computed microtomography indicated that local bone volume increased from 24.4% (13.86\u201332.45) to 32.8% (19.7\u201339.4), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). The same was true for presumed bone\u2010to\u2010implant contact, which was 34.38% (27.0\u201350.0) and 43.33% (31.6\u201354.2), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035). Histomorphometric analyses confirmed that the new bone area per total area increased from 34.78% (18.9\u201343.7) to 41.10% (23.5\u201354.0), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.102). This trend proceeds after 40\u2009days of osseointegration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings suggest that topical delivery of a cathepsin K inhibitor can support the early osseointegration phase in an ectopic rodent implantation model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70038","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T06:45:57Z","timestamp":1757054757000},"page":"1640-1650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Odanacatib Coating Supports Osseointegration of Implants: A Preclinical Study"],"prefix":"10.1111","volume":"36","author":[{"given":"Nat\u00e1lia","family":"dos Santos Sanches","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry Ara\u00e7atuba  S\u00e3o Paulo Brazil"},{"name":"Department of Oral Biology University Clinic of Dentistry, Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8881-4882","authenticated-orcid":false,"given":"Caroline Liberato","family":"Marchiolli","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry Ara\u00e7atuba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara Cristina Cunha","family":"Cervantes","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry Ara\u00e7atuba  S\u00e3o Paulo Brazil"},{"name":"University of Brazil  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina Ruiz Voms","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry Ara\u00e7atuba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Alves","family":"Berton","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry Ara\u00e7atuba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Est\u00e9fany Lopes Lemes","family":"do Prado","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry Ara\u00e7atuba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Kampleitner","sequence":"additional","affiliation":[{"name":"Karl Donath Laboratory for Hard Tissue and Biomaterial Research University Clinic of Dentistry, Medical University of Vienna  Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"},{"name":"Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation With AUVA  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisley \u00c1vila","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery S\u00e3o Paulo State University (UNESP), School of Dentistry Ara\u00e7atuba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry Ara\u00e7atuba  S\u00e3o Paulo 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