{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:24:17Z","timestamp":1787984657231,"version":"build-2784847793"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHL 168\u201012\/1"],"award-info":[{"award-number":["SCHL 168\u201012\/1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LI 916\/18\u20101"],"award-info":[{"award-number":["LI 916\/18\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the present study was to assess the effect of dual growth factor release from collagen\u2010based polyelectrolyte multilayer films (PEMs) on titanium implants on periimplant bone formation and angiogenetic activity in minipig mandibles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Disc shaped Ti implants (5\u2009\u00d7\u20097\u2009\u00d7\u20091\u2009mm) were coated with polyelectrolyte multilayer films and loaded with rhBMP\u20102, rhVEGF165, and a combination of both. Uncoated and unloaded Ti implants served as controls. The implants were inserted press\u2010fit into 5\u2009mm trephine cavities in minipig mandibles and evaluated after 4 and 13\u2009weeks for bone formation, bone implant contact, and periimplant expression of CD31.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 4\u2009weeks, there was no significant difference in periimplant bone formation nor bone\u2010implant contact between the different surface conditions. CD31 expression was significantly increased around PEM coated implants loaded with VEGF and BMP each. After 13\u2009weeks, bone implant contact and bone formation were significantly increased only around PEM coated implants with simultaneous release of BMP\u20102 and VEGF165. Expression of CD31 was significantly enhanced around all PEM coated implants loaded with growth factors regardless of the type or combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It is concluded that simultaneous release of rhBMP\u20102 and rhVEGF165 may be required to achieve significant improvement of periimplant bone formation and bone implant contact. Angiogenesis as reflected by CD31 expression is enhanced by both rhVEGF165 and rhBMP\u20102 to a similar extent without an additive effect of simultaneous release.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70045","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T14:33:09Z","timestamp":1757687589000},"page":"1-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual Growth Factor Release From Collagen Based Multilayer Films on Ti\u2010Surfaces Enhances Periimplant Bone Formation and Angiogenic Activity\u2014An Experimental In\u2010Vivo Study"],"prefix":"10.1111","volume":"37","author":[{"given":"Philipp","family":"Kauffmann","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery George\u2010Augusta\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-2301","authenticated-orcid":false,"given":"Susanne","family":"Wolfer","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery George\u2010Augusta\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5734-3053","authenticated-orcid":false,"given":"Christina","family":"Behrens","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery George\u2010Augusta\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery George\u2010Augusta\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dullin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology George\u2010Augusta\u2010University  G\u00f6ttingen Germany"},{"name":"Department of Diagnostic and Interventional Radiology University Hospital Heidelberg  Heidelberg Germany"},{"name":"Max Plank Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Schirmer","sequence":"additional","affiliation":[{"name":"Institute for Bioprocessing and Analytical Measurement Techniques  Heiligenstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Liefeith","sequence":"additional","affiliation":[{"name":"Institute for Bioprocessing and Analytical Measurement Techniques  Heiligenstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2008-7188","authenticated-orcid":false,"given":"Henning","family":"Schliephake","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery George\u2010Augusta\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712803413944"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2013.0070"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.08.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37411"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147803"},{"key":"e_1_2_9_7_1","unstructured":"Bierbaum S. 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