{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:11:34Z","timestamp":1791807094885,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The intention of this 10\u2010year prospective cohort investigation was to clinically and radiographically investigate the outcomes of a one\u2010piece zirconia implant system for single\u2010tooth replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A total of 65 patients received 66 single\u2010tooth implants restored with all\u2010ceramic crowns. Follow\u2010up assessments were conducted at the time of prosthetic delivery, after 1, 3, 5, and 10\u2009years. Peri\u2010implant soft tissue parameters were evaluated. To assess peri\u2010implant bone loss, standardized radiographs were taken at implant placement, prosthetic delivery, at the 1\u2010, 3\u2010, 5\u2010, and 10\u2010year follow\u2010ups. Statistical analysis was conducted using linear mixed regression models and Wilcoxon Signed Rank tests to compare differences over time and between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over the course of 10\u2009years, 16 implants were lost, yielding a cumulative survival rate of 73.3%. Fifteen patients were lost to follow\u2010up over the 10\u2010year period. The average marginal bone loss of the remaining implants was 1.09\u2009mm. Probing depth, attachment level, and bleeding showed an increase over time, while plaque index slightly decreased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given the high implant loss rate after 10\u2009years and the high occurrence of advanced bone loss observed in this study, the implant was not recommended for routine clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70049","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T04:45:23Z","timestamp":1759466723000},"page":"33-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ten\u2010Year Results of a Prospective Study on One\u2010Piece Zirconia Oral Implants for Single\u2010Tooth Reconstruction"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-4190","authenticated-orcid":false,"given":"Ralf\u2010Joachim","family":"Kohal","sequence":"first","affiliation":[{"name":"Medical Center \u2013 University of Freiburg, Center for Dental Medicine, Department of Prosthetic Dentistry, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agneta","family":"Lith","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Institute of Odontology, Sahlgrenska Academy Gothenburg University  G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9973-6266","authenticated-orcid":false,"given":"Futoshi","family":"Komine","sequence":"additional","affiliation":[{"name":"Department of Fixed Prosthodontics Nihon University School of Dentistry  Chiyoda\u2010Ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Fixed Prosthodontics Nihon University School of Dentistry  Chiyoda\u2010Ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt C.","family":"Spies","sequence":"additional","affiliation":[{"name":"Medical Center \u2013 University of Freiburg, Center for Dental Medicine, Department of Prosthetic Dentistry, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0011-4134","authenticated-orcid":false,"given":"Felix","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Medical Center \u2013 University of Freiburg, Center for Dental Medicine, Department of Prosthetic Dentistry, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstin","family":"Vach","sequence":"additional","affiliation":[{"name":"Medical Center \u2013 University of Freiburg Institute of Medical Biometry and Statistics  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.04.011"},{"key":"e_1_2_10_3_1","volume-title":"Practical Statistics for Medical Research","author":"Altman D. G.","year":"1999"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201702512"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17\u20100739"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13030562"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/coatings14080995"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2011.01839.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13790"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1551\u20102916.2009.03278.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12098"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010023\u201002986\u20100"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.12.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14258"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010020\u201003769\u20105"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066844"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12565"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517740560"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.3503"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2024.105434"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2020.01.013"},{"key":"e_1_2_10_23_1","first-page":"S155","article-title":"A Systematic Review of Survival of Single Implants as Presented in Longitudinal Studies With a Follow\u2010Up of At Least 10\u2009Years","volume":"9","author":"Hjalmarsson L.","year":"2016","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2015.12.004"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2019.03.008"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1466417"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100501.000.00934.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.01.020"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40496\u2010020\u201000289\u20109"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2012.01876.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb15050122"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33512"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12815"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14010045"},{"key":"e_1_2_10_35_1","first-page":"150","article-title":"Consensus Statements and Recommended Clinical Procedures Regarding Implant Survival and Complications","volume":"19","author":"Lang N. P.","year":"2004","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00202.2012"},{"key":"e_1_2_10_37_1","first-page":"199","volume-title":"Tissue Integrated Prostheses: Osseointegration in Clinical Dentistry","author":"Lekholm U.","year":"1985"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12720"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010023\u201005401\u20108"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13305"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c02416"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12597"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2007.01346.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12364"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0142\u20109612(98)00010\u20106"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2017.10.008"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13071671"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.9228"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13431"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12954"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708\u20108208.2005.tb00070.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13330"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12319"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2008.01544.x"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13433"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13871"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.a38057"},{"issue":"7","key":"e_1_2_10_58_1","first-page":"523","article-title":"Nonalloyed Titanium as a Bioinert Metal\u2014A Review","volume":"36","author":"Tschernitschek H.","year":"2005","journal-title":"Quintessence International"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1997.2.1.291"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.70049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/clr.70049","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.70049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:54:28Z","timestamp":1773719668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.70049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,2]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/clr.70049"],"URL":"https:\/\/doi.org\/10.1111\/clr.70049","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,2]]},"assertion":[{"value":"2025-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}